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 (mī′krō-glē′ə, -glī′-)
Small neuroglial cells of the central nervous system that have long processes and act as phagocytes at sites of neural damage or inflammation, destroying pathogens and damaged cells.

mi′cro·gli′al adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Anatomy) one of the two types of non-nervous tissue (glia) found in the central nervous system, having macrophage activity. Compare macroglia
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.microglia - neuroglial tissue of mesodermal origin that can become phagocyticmicroglia - neuroglial tissue of mesodermal origin that can become phagocytic
glia, neuroglia - sustentacular tissue that surrounds and supports neurons in the central nervous system; glial and neural cells together compose the tissue of the central nervous system
microgliacyte - a cell of the microglia that may become phagocytic and collect waste products of nerve tissue
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Its mode of action is to attenuate microglial and astroglial mediated neuroinflammation, resulting in reduced burden of neuropathic proteins such as superoxide dismutase-1, alpha-synuclein and beta-amyloid in animal models of neurodegenerative disorders such as ALS, Parkinson's disease and Alzheimer's disease, respectively.
Among the topics are the function of prion protein and the family member shadoo, the effect of microglial inflammation in prion disease, clinical aspects of human prion diseases, bovine spongiform encephalopathy and scrapie, and chronic wasting disease: the current assessment of transmissibility.
MGTA-456, a First-in-Class Cell Therapy with High Doses of CD34+ CD90+ Cells, Enhances Speed and Level of Human Microglia Engraftment in the Brains of NSG Mice: Stem cell transplant is a standard of care in inherited metabolic disorders, and engraftment of microglial cells, which produce the deficient enzyme in the brain, after transplant is crucial for successful outcomes in patients.
Individuals who are at high risk for psychosis and schizophrenia have measurable increases in inflammatory microglial activity.
Strategies that regulate microglial function may be useful for the prevention of neurological dysfunction in a variety of CNS injuries or neurodegenerative diseases (10).
Summary: Washington D.C [USA], Sep 01 (ANI): A recent study has highlighted the importance and activities of the so-called microglial cells in brain aging.
PPAR-[gamma] activation that mediated through 15-deoxy PGJ2 also inhibits LPS-stimulated inducible nitric oxide synthase expression and TNF-[alpha] production as well as IFN-[gamma]-induced expression of major histocompatibility complex class II antigens, by preventing the activation of the transcription factors signal transducer and activator of transcription 1 and NF-kB, which is also a regulator of microglial inflammation and functions.
Fractalkine is essential for microglial cell migration.
In 2011, it was demonstrated that the clock genes are constitutively expressed in both cultured murine microglia and the microglial cell line BV-2 cells.
A number of in vitro and in vivo studies reported that microglial cells are the main source of C1q in adulthood and normal aging (Table 2) [30-32].