Ishii et al., "JTT-130, a novel intestine-specific inhibitor of microsomal
triglyceride transfer protein, suppresses food intake and gastric emptying with the elevation of plasma peptide YY and glucagon-like peptide-1 in a dietary fat-dependent manner," Journal of Pharmacology and Experimental Therapeutics, vol.
In vitro microsomal
analytes were eluted on a NovaPak phenyl column (5 [micro]m, 150 x 3.9 mm) by using a mobile phase composed of a 75: 25 mixture of acetonitrile and water (1.5% glacial acetic acid and 0.1% triethylamine), flowing at 1 mL/min.
The metabolism of [1-[sup.14]C] eicosa-11,14-dienoic acid was later investigated using rat liver microsomal
Finally, thyroid gland abnormalities, including abnormal results for TFT and autoantibodies, such as thyroglobulin antibody (TGA, <115 IU/mL), TSH receptor antibody (TSH-RA, <1.5 U/L), and anti-thyroid microsomal
autoantibody (TPO-Ab, <34 IU/mL), were compared between the three groups.
Sugiura et al., "Endothelial microsomal
prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate," Journal of Neuroscience Research, vol.
ethanol oxidizing system (MEOS), which is generated by hepatocytes and hepatic enzymes including CYP2E1, CYP1A2, and CYP3A, is an alternate pathway for ethanol metabolism (Lieber 1999; Garcia-Banuelos et al.
Further antibody and serology testing of anti microsomal
antibodies, thyroglobulin, Lyme serology, and perineoplastic antibodies were negative.
This follows the approval of lomitapide (Juxtapid), a microsomal
triglyceride transfer protein (MTP) inhibitor approved in December, to reduce LDL cholesterol, total cholesterol, apolipoprotein B, and non-HDL cholesterol in patients with HoFH.
Expression of NQO-1, GST-alpha, gamma-glutamylcysteine synthetase-heavy and -light chains, and microsomal
GST was assessed by Northern blot analysis.
The identified enzymes involved in acetaldehyde production included alcohol dehydrogenase (ADH) and xanthine oxidoreductase (XO) in the cytosolic fraction and the flavoenzyme NADPH oxidase and catalase in the microsomal
Researchers at the Perelman School of Medicine at the University of Pennsylvania, who led the study, revealed that lomitapide, a first-in-class microsomal
triglyceride transfer protein (MTP) inhibitor, substantially and stably reduced LDL cholesterol (the "bad" cholesterol) in patients with the orphan disease homozygous familial hypercholesterolemia (HoFH).