mifepristone


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mi·fep·ri·stone

 (mĭ-fĕp′rĭ-stōn′)
n.
A synthetic steroid, C29H35NO2, that blocks the action of progesterone and is used in combination with misoprostol to induce abortion in early pregnancy. Also called RU 486.

[(a)mi(no) + alteration of phe(nyl) + pr(opyl) + alteration of est(radiol) + -one.]

mifepristone

(mɪˈfɛprɪˌstəʊn)
n
(Pharmacology) an antiprogestogenic steroid, used in the medical termination of pregnancy. Formula: C29H35NO2
[C20: from aminophenol + propyne + oestradiol + -one]

mif•e•pris•tone

(ˌmɪf əˈprɪs toʊn)
n.
an antigestational drug that prevents a fertilized egg from attaching to the uterine wall by blocking the action of progesterone.
[1985–90; probably alter. of (a)mi(no)phe(nol) + pr(opyl) + est(radiol) + -one]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mifepristone - an abortion-inducing drug (trade name RU_486) developed in Francemifepristone - an abortion-inducing drug (trade name RU_486) developed in France; when taken during the first five weeks of pregnancy it blocks the action of progesterone so that the uterus sloughs off the embryo
aborticide, abortifacient, abortion-inducing drug - a drug (or other chemical agent) that causes abortion
Translations

mifepristone

n mifepristona
References in periodicals archive ?
More than three quarters (153) of those with such experience indicated those women were using mifepristone (RU486) and/or misoprostol, the abortion drugs currently sold in the U.S., but legally available only through an abortionist who meets certain conditions laid down by the Food and Drug Administration (FDA).
Mifepristone is a progesterone antagonist with high efficacy; it has been widely used in clinics for suppressing endometrial hyperplasia and terminating early pregnancy (Cameron et al., 1996; Boggavarapu et al., 2016).
The FDA-approved regimen for medication abortion is sanctioned for use up to 70 days since the patient's last menstrual period and consists of two medications currently available by prescription: mifepristone, which works by blocking progesterone (a hormone needed for a pregnancy to continue); and misoprostol, taken 24-48 hours later, which induces contractions and ends the pregnancy.
Shares down 26.5% YTD and saw notable volatility in February on reports TEVA was developing a generic version of KORLYM Mifepristone tablets.
In a randomized trial of women with early pregnancy loss, pretreatment with mifepristone before misoprostol was superior to misoprostol alone at achieving gestational sac expulsion by the time of the first follow-up visit without additional intervention.
A combination of mifepristone and misoprostol can help women suffering from miscarriage by decreasing the need for surgical intervention to complete the painful process, a new study has shown.
WEDNESDAY, June 6, 2018 (HealthDay News) -- Mifepristone pretreatment improves medical management of early pregnancy loss, according to a study published in the June 7 issue of the New England Journal of Medicine.
[2] Most commonly used and studied regimen includes that of mifepristone (antiprogesterone) and misoprostol (Synthetic 15-deoxy-16-hydroxy-16-methyl analogue of PGE1).
The article uses the Bangladeshi government's definition of menstrual regulation (MR): "the procedure of regulating the menstrual cycle when menstruation is absent for a short duration." (1) MR is provided using manual vacuum aspiration up to 12 weeks from the last menstrual period if provided by a physician or a dual regimen of mifepristone and misoprostol up to nine weeks after a woman's last menstrual period.
The Arkansas law is based on a controversial method of stopping the effects of a medication abortion by flooding a woman's body with progesterone after she has taken mifepristone, the first of two drugs to trigger pregnancy termination.
Here we report a case of autonomous cortisol secretion due to an adrenal adenoma in which medical therapy with the competitive glucocorticoid receptor antagonist mifepristone resulted in biochemical remission of NAFLD.
Objective: To evaluate the clinical therapeutic effects of mifepristone combined with gestrinone on patients with endometriosis.