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Adj.1.misanthropical - believing the worst of human nature and motivesmisanthropical - believing the worst of human nature and motives; having a sneering disbelief in e.g. selflessness of others
distrustful - having or showing distrust; "a man of distrustful nature"; "my experience...in other fields of law has made me distrustful of rules of thumb generally"- B.N.Cardozo; "vigilant and distrustful superintendence"- Thomas Jefferson
2.misanthropical - hating mankind in generalmisanthropical - hating mankind in general    
ill-natured - having an irritable and unpleasant disposition
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I now recollected that I had business with Robert Wilson, concerning the purchase of a certain field adjoining my farm - a business I had been putting off from day to day; for I had no interest in anything now; and besides, I was misanthropically inclined, and, moreover, had a particular objection to meeting Jane Wilson or her mother; for though I had too good reason, now, to credit their reports concerning Mrs.
On the first occasion it was at my charterers, where he came in misanthropically to get paid for towing out a French barque the day before.
He claims to be past taking pleasure in wealth or women and misanthropically observes "Fain would I fly the haunts of men, / I seek to shun, not hate mankind, / My breast requires the sullen glen, / Whose gloom may suit a darken'd mind" (CPW I: 123).