Vaginal administration of misoprostol
(25 [micro]g initial dose, 50 [micro]g subsequent doses) may be superior to the buccal route, according to results of the IMPROVE trial, a prospective randomized placebo-controlled study of 300 women with a singleton vertex fetus requiring cervical ripening for induction of labor at term.
Induced Mid Trimester (MI-MT) abortion, previous caesarean and non-caesarean cases, comparison of complications.
Medical management is done by Misoprostol
alone, which is a prostaglandin E1 analogue, and preferred over earlier medications like methotrexate and mifepristone (4).
In a randomized trial of women with early pregnancy loss, pretreatment with mifepristone before misoprostol
was superior to misoprostol
alone at achieving gestational sac expulsion by the time of the first follow-up visit without additional intervention.
A combination of mifepristone and misoprostol
can help women suffering from miscarriage by decreasing the need for surgical intervention to complete the painful process, a new study has shown.
Schreiber, M.D., M.P.H., from the University of Pennsylvania in Philadelphia, and colleagues randomized 300 women who had an anembryonic gestation or in whom embryonic or fetal death was confirmed to receive pretreatment with mifepristone, administered orally followed by misoprostol
administered vaginally, or to misoprostol
alone administered vaginally.
There have been many studies to evaluate the efficacy of misoprostol
for labour induction in various doses, routes and intervals of administration, suggesting that misoprostol
is effective, but there is still a concern that misoprostol
may increase the rates of tachysystole and hyperstimulation and a search for ideal dose and mode is still on.
To obtain cervical dilation, several alternatives, including mechanical dilators, intracervical osmotic dilators, mifepristone, and misoprostol
can be used (7-9).
An article in this edition describes two cases of serious genital tract injury that occurred with standard doses of misoprostol
, commonly sold as Cytotec, when used to achieve evacuation of the uterus in the second trimester.
Objective: To compare the safety and effectiveness of expectant management with medical management by misoprostol
in cases of first trimester miscarriage.
CHICAGO -- Misoprostol
could be a treatment option for healing intestinal bleeding that is associated with regular aspirin use, a small study showed.