We speculate that the low-level sequence variation observed may be linked with an on-going balance between mitochondrial DNA
damage and repair, and may be indicative of the baseline activity of the different repair mechanisms taking place in the mitochondria.
Ciprofloxacin stopped this normal maintenance and transcription of mitochondrial DNA
by changing mtDNA topology, causing impaired mitochondrial energy production and blocking cellular growth and differentiation.
On the other hand, interesting studies have also been reported regarding the effects of mitochondrial DNA
on the formation of brain tumors (4,5).
In this study, we investigated the diversity and phylogeography of four geographic ecotype populations of the Naqu yak (133 individuals) using an 811-bp mitochondrial DNA
D-loop region sequence.
Analysis of mitochondrial DNA
A8344G point mutation in 6 cases with myoclonic epilepsy and ragged-red fibres disease (in Chinese).
As humanin is encoded within the mitochondrial genome, the research team examined the mitochondrial DNA
for common genetic variations known as single nucleotide polymorphisms (SNPs) that could explain the differences between humanin levels.
Human cells contain two types of DNA - nuclear DNA that's found in the nucleus, and mitochondrial DNA
, which is present in the cells' energy-producing mitochondria. Unlike nuclear DNA, which is inherited in equal quantities from both parents, the mitochondrial DNA
- present outside the nucleus - is inherited only from the mother.
Unlike other subcellular organelles, such as Golgi, lysosomes, and endosomes, mitochondria individually encapsulate their own genome, referred to as mitochondrial DNA
For a "three-parent baby," getting disease-free mitochondrial DNA
from a surrogate may do more than just avert disease: For better or for worse, a donor's mitochondria could also affect the course of aging, new research shows.
HELSINKI, FINLAND -- Mitochondrial DNA
level appears to be a useful biomarker for in vitro fertilization embryo viability, according to findings from a blinded prospective nonselection study.
The team at the Oregon Health & Science University has discovered that induced pluripotent stem, or iPS, cells, a type of stem cell derived from patients' skin or blood cells contain faulty mitochondrial DNA
Detection of Y chromosome microdeletions and mitochondrial DNA
mutations in male infertility patients.