They comprise an osteoconductive matrix that acts as a filler to promote wound healing; osteoinductive proteins which support mitogenesis
of identical bone cells; and osteogenic cells that form the bone in the appropriate environment.
Normal wound healing is a complex process involving a series of coordinated events that systematically move through the four distinct stages of wound healing, involving phagocytosis, chemotaxis (movement of cells in response to a stimuli), mitogenesis
(induction of cell division), and a synthesis of the extracellular matrix components (Enoch & Leaper, 2005).
Synthetic peptides bind to high.affinity thrombin receptors and modulate thrombin mitogenesis
. Pept Res 1988;1:65-73.
(10) Moreover, BMSCs can produce some growth factors and cytokines for mitogenesis
, angiogenesis, and anti-apoptosis.
When their job is complete, and they are tired out, they undergo mitophagy (removal of these retired specialized cells) to make room for mitogenesis
(creation of new mitochondria)--all in an efficient, quality-controlled process that keep up with our energy needs.
HIF, a transcription factor capable of activating a battery of genes involved in glucose uptake and metabolism, extracellular pH control, angiogenesis, erythropoiesis, mitogenesis
, and apoptosis, is expressed ubiquitously.
The xenoestrogen bisphenol A induces inappropriate an-drogen receptor activation and mitogenesis
in prostatic adeno-carcinoma.
Similarly, LMWH treatment was shown to inhibit FGF-induced mitogenesis
of tumor derived endothelial cells in a time and concentration dependent manner .
Benito, "Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor-I-induced differentiation, but not for mitogenesis
, in fetal brown adipocytes," Molecular Endocrinology, vol.
Sharif, "Substance P-induced mitogenesis
in human astrocytoma cells correlates with activation of the mitogen-activated protein kinase signaling pathway," Cancer Research, vol.
In these cell lines, nongenomic pathways are involved in mitogenesis
, survival, and differentiation.
Tomioka, "Unique macrophages different from M1/M2 macrophages inhibit T cell mitogenesis
while upregulating Th17 polarization," Scientific Reports, vol.