However, the strong physiological action and mitogenicity
associated with BN-based GRPR-agonists  and the superior tumor uptake seen for somatostatin antagonists  led to a paradigm shift towards the use of potent GRPR antagonists in the development of BN analogs during recent years .
In the case of mitogenicity
study, GM in nonconfluent cells was directly replaced by 2% BSA (w/v)/DMEM with or without experimental factors.
Contribution of each of four Superantigens to Streptococcus equi-induced mitogenicity
, gamma interferon synthesis, and immunity.
Hollema et al., "Ras/ ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity
, and transformation," The Journal of Biological Chemistry, vol.
(15) The property of "mitogenicity
," or the presence of any mitoses in the dermis, was included in the definition of VGP because a few cases were found to have metastasized that were mitogenic but not tumorigenic.
bulgaricus serves as a functional bacterial component (Kitazawa et al., 1998; Uemuraet al., 1998), and exerts beneficial immunological effects including the enhancement of lymphocyte mitogenicity
(Kitazawa et al., 1998) and macrophage function (Kitazawa et al., 2000; Nishimura-Uemura et al., 2003) .