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Any of a group of antibiotics produced by the soil actinomycete Streptomyces caespitosus that inhibit DNA synthesis and are used against bacteria and cancerous tumor cells.

[Probably mito(sis) + -mycin.]


(Pharmacology) pharmacol any of the antibiotics that come from Streptomyces caespitosus
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Noun1.mitomycin - a complex of antibiotic substances obtained from a streptomyces bacterium; one form (trade name Mutamycin) shows promise as an anticancer drug
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
References in periodicals archive ?
20) They retrospectively examined the timing of first mitomycin C (MMC) instillation in patients who received a total of 5 instillations of MMC followed by BCG or interferon-[alpha]2b/BCG therapies, using data from a prospective randomized trial.
Mitomycin C (MMC) is one of the most important and commonly-used anticancer drugs.
The Phase 1 trial is a two-part, open-label, dose-escalation study designed to evaluate the safety and tolerability of CAVATAK administered alone, as well as in combination with the standard chemotherapy, mitomycin C, in patients with NMIBC.
Rosales, and Donald Braun, PhD will deliver a presentation titled "Regulation of Wnt pathway components may be linked to augmented suppression of colorectal cancer cell proliferation by combination treatment of Resveratol and Mitomycin C.
Mitomycin C Induction of Bacterial Lysis, Shiga Toxin 1a Production, and Prophage Induction
Results of subsequent trials have led to the recommendation that standard treatment for carcinoma of the anal canal is radiation to a dose of 45 - 50 Gy with a combination of 5 fluorouracil (5FU) and mitomycin C chemotherapy.
Around half were given two commonly used chemotherapy drugs - fluorouracil and mitomycin C in addition to radiotherapy (chemoradiotherapy).
They discuss early approaches, pterygium's pathogenesis, the use of fibrin tissue adhesive, conjunctival autograft techniques, amniotic membrane techniques, mitomycin and 5-fluorouracil adjuncts, and managing complications and conjunctival chalasis.
Some laryngeal webs have been successfully treated in a single stage with endoscopic lysis and topical application of mitomycin C.
He served for 12 years at Bristol Myers, where in addition to developing Amoxicillin and Chephadroxil, he was instrumental in licensing their original anti-cancer line of products, including Mitomycin, Etoposide, and Bleomycin.
When they treated cells with mitomycin C, which promotes DNA cross-linking, that protein, then known as KIAA1018, gathered at damage sites.
21) In a meta-analysis, it was concluded that at least 1 year of maintenance BCG was required to show the superiority of BCG over mitomycin C (MMC) in preventing recurrence or progression.