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Any of a group of antibiotics produced by the soil actinomycete Streptomyces caespitosus that inhibit DNA synthesis and are used against bacteria and cancerous tumor cells.

[Probably mito(sis) + -mycin.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pharmacology) pharmacol any of the antibiotics that come from Streptomyces caespitosus
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mitomycin - a complex of antibiotic substances obtained from a streptomyces bacterium; one form (trade name Mutamycin) shows promise as an anticancer drug
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
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References in periodicals archive ?
UGN-102: The Company continues to enroll patients in its Phase 2b OPTIMA II clinical trial of investigational agent UGN-102 (mitomycin gel) for intravesical instillation as a first line-chemoablation agent in the treatment of patients with intermediate risk low-grade non-muscle invasive bladder cancer (LG NMIBC), a form of disease associated with a high risk of recurrence.
Nine received the CVA21 alone, via a catheter into the bladder, while the final six received CVA21 combined with a low dose of a chemotherapy drug called mitomycin C.
Intravesical Mitomycin 40 mg was instilled within 24 hours.
Their results support that in NMIBC, intravesical BCG therapy for variant histology has better prognosis in terms of progression and cancer-specific survival than other intravesical treatments (mitomycin C and thiotepa) with no need for additional treatment.
Many studies supported the usefulness of Mitomycin C in preventing postoperative adhesions and scarring.
Mitosol (mitomycin for solution) 0.2mg/vial is provided as part of a Kit for Ophthalmic Use.
After maximal transurethral resection of bladder tumour (TURBT), they received 4 courses of chemotherapy with mitomycin and 5 fluorouracil, followed by concurrent chemoradiation using same chemotherapy received 50 Grays in 20 fractions.
Till now, trabeculectomy is still the most efficient option for those with progressive glaucoma.[6] Cicatrix is the major cause of postoperative bleb failure and significantly affects the long-term success rate of trabeculectomy.[7],[8],[9],[10] The use of antimitotic agents such as 5-fluorouracil and mitomycin C (MMC) has been widely accepted as the golden standard of trabeculectomy, apparently reducing the incidence of scar formation and enhancing bleb surviving rate.
The commonly preferred regimen for CRT comprises 5-fluorouracil (5-FU) and mitomycin (MMC).
At 63 months of age, another DLB showed a grade two subglottic stenosis with recurrence of the subglottic hemangiomas requiring balloon dilation, topical mitomycin C application, and injection of Kenalog-40/celestone solution.