Based on these results, they teamed up and together examined possible causes of these mitotic
Analysis of the change over the dosing period of the basal epithelium mitotic
count, a secondary endpoint and a cellular driver of psoriasis pathology, showed a mean reduction of 2.25 cells/mm2 in patients who received EDP1815 compared to no change in patients receiving placebo.
A Grade II tumor with a mitotic
index (more on this below) of greater than 5 should be treated as a Grade III tumor.
Most cases demonstrated minimal atypia and low mitotic
rate (0-1/10 high power field (hpf)), consistent with low-grade features.
Microscopically, five tumors exhibited diffuse growth pattern, four showed prominent mitotic
activity (6-40/10 high-power fields [HPFs]), one had sarcomatous components, and one was mixed with mucinous cystadenoma components [Figure 1]b.
In the present study, 1H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazone] derivatives were evaluated for their anticancer activities and different cell death mechanisms using cell kinetic parameters including the cell index, mitotic
index, labelling index and apoptotic index.
Stochastic mode of organelles distribution in daughter cells has been shown to occur through mitotic
spindles like hitch-hiking with chromosomes.2 The question arises: where do the organelles disappear during different phases of cell cycle leaving an open space for the drama of cell division to occur?
Currently, Ki-67 proliferation index, either by manual examination or digital image analysis of Ki-67 immunohistochemistry, is not implemented for classification, in contrast to the GEP NETs that are classified as grade 1, 2, or 3, on the basis of mitotic
count and Ki-67 labeling index (LI).
The ICAP classification identifies three major fluorescence patterns; nuclear (true ANA), cytoplasmic, and mitotic
. Each category is subdivided into groups and subgroups of patterns, creating a classification tree.
Rare autoantibody patterns were evaluated as mitotic
(midbody, spindle fibers, centriole and rod and rings), nuclear (PCNA-like) and cytoplasmic (anti-golgi, anti-actin) in our retrospective analyses.
1.5 mm) as was the median mitotic
index (5 mitotic
figures per mm2 vs.