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It is a proliferative disorder of unknown etiology, and it is usually monarthric. Approximately 80% of cases involve the knee; the hip, ankle, foot, hand, elbow, and shoulder account for most other cases.
It represents a reactive process of the synovial tissue, it usually involves the knee or other major joint, and it is usually monarthric. Although pigmented villonodular synovitis is histologically benign, it can be a very aggressive lesion, capable of causing extensive bone destruction and capable of widespread infiltration of surrounding tissues.