When a muscle is stretched, the earliest muscle contraction (e.g., 20 ms in biceps brachii) occurs due to the involuntary activation of monosynaptic
Transmission of input from nociceptors to spinal neurons that project to the brain is mediated by direct monosynaptic
contact or by multiple excitatory or inhibitory interneurons.
H reflex is homologous to the monosynaptic
reflex in the spinal cord, (62) which enables us to investigate the motoneuron activity in the spinal cord in humans in an awake state.
Pettersson et al., "Dexterous finger movements in primate without monosynaptic
corticomotoneuronal excitation," Journal of Neurophysiology, vol.
Roncagliolo, "Immature developmental pattern of the monosynaptic
reflex in isolated spinal cord of glial mutant taiep rats," Developmental Brain Research, vol.
Studies investigating spinal excitability, as measured by monosynaptic
reflex activity (e.g., the Hoffmann reflex or cervicomedullary-evoked potentials), have reported inconclusive results and seem largely dependent on the muscle (distal versus proximal) [10, 26, 31].
Rabies Virus Reveals Premotor Network Organization and Synaptic Specificity of Cholinergic Partition Cells.
Pierrot-Deseilligny, "Sensitivity of monosynaptic
test reflexes to facilitation and inhibition as a function of the test reflex size: a study in man and the cat," Experimental Brain Research, vol.
Each CA1 was further partitioned into distal (layer size 20 x 20) and proximal (layer size 20 x 20) subdivisions that received monosynaptic
inputs from the LEC and MEC, respectively.
Electrical stimulation of the external capsule, including infralimbic mPFC inputs into the amygdala, resulted in a non-N-methyl-D-aspartate (non-NMDA) receptor-mediated monosynaptic
excitatory synaptic response (EPSC) in dorsomedial ITC cells and non-NMDA receptor-driven synaptic inhibition (ipse) of CeLC neurons .
Benzodiazepine decreases monosynaptic
and polysynaptic reflexes by increasing presynaptic GABA inhibition a similar action to Baclofen.
Cardoso et al., "Monosynaptic
tracing using modified rabies virus reveals early and extensive circuit integration of human embryonic stem cell-derived neurons," Stem Cell Reports, vol.