Under the agreement, Eisai and Merck will develop and commercialize LENVIMA jointly, both as monotherapy
and in combination with Merck's anti-PD-1 therapy, KEYTRUDA.
Innate immune activation with RGX-104, coupled with a reduction in tumor blood vessels, resulted in anti-tumor activity as a monotherapy
as well as synergy with checkpoint inhibitors in several drug-resistant mouse models.
M2 EQUITYBITES-September 15, 2017-UCB's new antiepileptic drug BRIVIACT approved by US FDA as monotherapy
treatment for partial-onset seizures in adults
announced today detailed results from ORAL Strategy, a head-to-head, noninferiority Phase 3b/4 study of XELJANZ (tofacitinib citrate) 5 mg twice daily (BID) as monotherapy
or in combination with methotrexate (MTX) compared to Humira plus MTX in the treatment of moderate to severe rheumatoid arthritis (RA).
OBJECTIVE: Evaluate the efficacy of L-methylfolate in combination with SSRI or SNRI compared to SSRI or SNRI monotherapy
in a major depressive episode.
Glycopyrrolate, a long-acting muscarinic antagonist, is available as monotherapy
Patients with type 2 diabetes treated with metformin as a monotherapy
are at a decreased risk for cardiovascular mortality, compared with those on sulfonylurea monotherapy
, according to a report in the Annals of Internal Medicine.
An open-label randomized phase III trial showed the combination of BRAF inhibitor dabrafenib with MEK inhibitor trametinib in patients with BRAF V600E or V600K mutant melanoma resulted in a significant reduction in death rates at 12 months compared with monotherapy
with BRAF inhibitor vemurafenib (hazard ratio, 0.
Similar observations have been reported in the treatment of inflammatory bowel disease, where early use of infliximab monotherapy
has given way to a standard of care that includes concomitant immunosuppressives.
NEW YORK - Tocilizumab monotherapy
is a viable alternative for patients with moderate to severe rheumatoid arthritis who have not responded to methotrexate in use with the biologic, according to Dr.
A/INSUFFICIENT EVIDENCE exists to determine which specific combinations most effectively decrease cardiovascular morbidity and mortality, although combinations of hypertension medications at lower doses generally reduce cardiovascular outcomes (stroke, coronary heart disease) more than monotherapy
(strength of recommendation [SOR]: A, large meta-analyses).
COMBINATION THERAPY BEATS MONOTHERAPY