morpholine


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morpholine

(ˈmɔːfəˌliːn)
n
(Biochemistry) a colourless liquid, formerly used as an emulsifier to provide a glossy coating to waxes
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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As shown in Table-2, it can be found that morpholine ring and benzene ring (single or double) without any substituent group, including electrophilic/nucleophilic substitution, possibly no contribute to antifungal activity, because the compounds merely containing these rings do not reveal any antifungal activity.
Synthesis, spectral characterization, and in vitro antibacterial and antifungal activities of novel 1, 3-thiazine-2-amines comprising morpholine nucleus.
Unlike thiurams or morpholine, Rhenogran CLD-80 does not generate carcinogenic N-nitrosamines during vulcanization, nor do the vulcanizates show any blooming.
Morpholine (tetrahydro-2H-1,4-oxazine), a heterocyclic secondary amine, is a colorless, hygroscopic, alkaline, oily liquid at normal temperature and pressure with an ammoniacal odor and is miscible with water and organic solvents in any ratio [1].
Compound 2 reacted with morpholine using [Na.sub.2]C[O.sub.3] as base in refluxing anhydrous ethanol to afford compound 3.
The bromide 32 was subjected to palladium-catalyzed coupling with morpholine (33), stannous nitro reduction, condensation with benzoyl isothiocyanate, bromine promoted formation of the benzothiazole ring, and installation of the piperidine ring through intermediate 38.
Aprepitant is metabolized largely by cytochrome P450 3A4 isoform (CYP3A4), which occurs mainly by oxidation at its morpholine ring and its side chains [19].
Reboxetine (a-ariloxybenzyl derivative of morpholine) is a norepinephrine reuptake inhibitor and also a norepinephrine transporter inhibitor, indicated in the therapy of unipolar depression, in panic and attention deficit hyperactivity disorders (4).
Gefinitib has three biotransformation pathways such as metabolism of the N-propyl morpholine group, demethylation of the quinazoline methoxy substituents, and oxidative defluorination of the halogenated phenyl group classes.