: Towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin
In animal and human experiments, erythromycin is believed to act on the motilin
In addition to the GH-inhibiting effect, somatostatin influences glucose metabolism by inhibiting glucagon secretion (5, 6) and suppresses release of insulin-like growth factor-1 (IGF-1) and several hormones, including serotonin, vasoactive intestinal polypeptide (VIP), gastrin, insulin, glucagon, secretin, and motilin
(1, 3, 7, 8).
, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon.
9] For instance, cholecystokinin secreting cells, motilin
secreting M cells, and neurotensin secreting N cells are found in the small intestine, but are absent in the large intestine.
After 14 days of feeding, the serum motilin
, gastrin and vitamin D levels of both groups all increased, with significant intra-group and inter-group differences.
Ghrelin and motilin
in the gastrointestinal system.
Of all the candidate genes for growth traits on chromosome 1, we herein focused our investigation on the motilin
receptor (MLNR, chr 1: 173.
Also, physical activity could influence the density of some of the hormones including vasoactive intestinal polypeptide, secretin, pancreatic polypeptide, somatostatin, gastrin, glucagon, catecholamines, motilin
, prostaglandins, and endorphins that are effective in both bowel function and defecation (21).
20] The role of motilin
in motor function of ICU patients may be of particular importance because of the regular use of the motilin
agonist erythromycin as a prokinetic agent in ICU.
Effect of Shugan Hewei decoction on motilin
and gastrin in blood of functional dyspepsia rats.
Another therapeutic effect of octreotide is suppression of secretion of gastrin, serotonin, intestinal peptides, and motilin
(Karch, 2011), decreasing postprandial gastrointestinal blood flow to help with pressure reduction within the gastroesophageal varices (Vorobioff et al.