The company will commence its planned global multicentric
Phase IIb study in septic shock patients later this year to demonstrate efficacy of nangibotide and bring a clinically relevant proof of clinical activity in septic shock patients.
Contextual Biblical Hermeneutics as Multicentric
Dialogue: Towards a Singaporean Reading of Daniel
Kaposi sarcoma is a multicentric
tumor caused by Kaposi sarcoma-associated herpesvirus, also called human herpesvirus-8.
On gross examination single nodular lesions were identified in 12 cases (27.2%), focal lesions in both lobes (multicentric
) in 7 cases (15.9%) and, more than one lesion in the same lobe (multifocal) in 11 cases (25%).
mucocutaneous neoplasia originating in the endothelium, KS is reported to present in four clinical forms: classic, iatrogenic (post-transplant), endemic, and epidemic.
This prospective multicentric
study confirms that the three-injection protocol is effective enough to achieve a good result and to minimize the cost of the treatment.
The American Joint Committee on Cancer (AJCC) defines multifocal invasive breast tumors as "multiple simultaneous ipsilateral carcinomas that can be unambiguously demonstrated to be macroscopically distinct and measurable using available clinical and pathological techniques." (1) The detection of multifocal and multicentric
breast cancers has increased, given the advances in imaging techniques in recent years.
The disease can be unicentric or multicentric
, in the latter it may be associated with human herpes virus 8 (HHV-8) or human immunodeficiency virus (HIV) infection.
(in lymph nodes throughout the body as well as organs with concentrations of lymphoid tissue)
We report a case of multicentric
rhinosporidiosis involving the nasal cavity, oropharynx, larynx, and cheek skin without disseminated disease outside the head and neck.
Besides, differentiating multicentric
occurrence (MO) from intrahepatic metastasis (IM), multiomics profiling could provide essential information to evaluate the aggressiveness of existing lesions and apply personalized therapies as well as postsurgical treatment. D-HCC occurs as an occult disease, providing few specific clinical manifestations, it resembles cirrhotic nodules on imaging, resulting in frequent misdiagnosis.