According to the company, the PRGN-3005 UltraCAR-T is a multigenic
CAR-T cell treatment utilising its clinically-validated Sleeping Beauty system to co-express a chimeric antigen receptor, membrane-bound interleukin-15 (mbIL15) and a kill switch for better precision and control in targeting advanced ovarian cancer.
The recurrent appearance of recently characterized genes in these studies is probably due to the previous unavailability of clinical tests for gene analysis either individually or as part of a multigenic
panel that included the new loci associated with WDSTS (14).
Control of Pod Shattering Resistance in Chinese Rapeseed Germplasm Revealed by Genome-Wide Association and Linkage Analyses.
PRGN-3006 UltraCAR-T is a multigenic
CAR-T cell treatment utilizing Precigen's clinically-validated Sleeping Beauty system to co-express chimeric antigen receptor, membrane-bound interleukin-15, and a kill switch for better precision and control in targeting relapsed or refractory AML and higher risk MDS.
S100: A multigenic
family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.
A quantitative trait like yield being multigenic
is significantly affected by environmental factors.
Synthetic Genomics replicon RNA technology enables a tunable, multigenic
approach to elicit desired antigen expression and immune response for a variety of applications.
stans by characterizing the multigenic
family of these proteins for the species and producing varieties that carry mutations for each phytochrome (Shinomura, 1997), thereby identifying the types of phytochromes present and associating a physiological function to each one.
Donato, "S100: a multigenic
family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles," The International Journal of Biochemistry & Cell Biology, vol.
Selection of suitable candidate genes should continue in order to successfully delineate the genetic underpinnings of a multigenic
complex disorder like PCOS.
Huang et al., "Breast cancer risk associated with genotype polymorphism of the catechol estrogen-metabolizing genes: a multigenic
study on cancer susceptibility," International Journal of Cancer, vol.