Skeletal muscle fibers were multinucleated
. Oval shaped nuclei were peripherally located just beneath the cell membrane.
Microscopically, the tumor was found to have pleomorphic mononuclear cells with multinucleated
There were also multinucleated
giant cells, neutrophils, and eosinophils, as well as proliferation of connective tissue with marked collagen deposition, characterizing the lesion as dermatitis, panniculitis, and granulomatous myositis.
This leads to the formation of multinucleated
macrophages with tissue-remodelling signatures (herrtwich, cell 2016).
cells resembling syncytiotrophoblasts are common.
Histopathology of lesional skin showed collections of foamy histiocytes and occasional multinucleated
giant cell in dermis (Figure 4).
On the other hand, this compound increases vacuolization, DNA damage, the number of multinucleated
giant cells (MNGCs) (6), cell cycle delay (7), and the number of morphologically abnormal sperms and apoptotic cells (8).
Histologically, PXA is characterized by spindle cells, multinucleated
giant cells and foamy lipid-laden xanthomatous cells.
The typical inflammatory granulomatous response is a tissue chronic reaction that causes targeted lesions as a result of in situ persistence of injury by the pathogen agent, where predominantly the mononuclear phagocytic cells form aggregates of macrophages and multinucleated
giant cells, which in most cases are surrounded by lymphocytes, and depending on the time of development, they could display fibrosis (Williams and Williams, 1983; Perez-Torres et al.
Subsequent bronchoscopy with transbronchial biopsy showed multinucleated
giant cells associated with laminated concentric calcification (Schaumann bodies).
Histologically, the nodular lesions in the ileum showed severe granulomatous enteritis with large areas of necrosis and numerous multinucleated
giant cells (Figure, panel A).
Pathological findings confirmed PCI showing multiple gas-filled cysts in the submucosa and multinucleated
giant cells beside the cysts (Figure 8).