Chlorzoxazone, a centrally acting muscle relaxant act primarily at the level of the spinal cord and subcortical areas of the brain, where it inhibits multisynaptic
reflex arcs involved in producing and maintaining skeletal muscle spasm.
output pathways allow the SCN to drive rhythmic release of endocrine hormones (e.g., melatonin and glucocorticoids) [81, 83-86], which in turn, impart rhythmic control over energy expenditure, metabolic activity, and both immune and stress responses [87-90].
The BG and the cerebellum modulate the activity of largely overlapping cerebral cortical areas through multisynaptic
loops, which were traditionally assumed to be anatomically and functionally separate .
Working with chronically implanted, freely moving, naturally awake, and sleeping cats they showed that in absence like seizures the spike-wave discharges "originate in the neocortex and are disseminated through monooligo and multisynaptic
intracortical circuits, before they spread to the thalamus and exhibit generalized features" The cortical origin have been supported by the Steriade group with several ablational experiments, and they also stressed the focal to widespread propagation dynamics in the seizures that was later confirmed in several human reports and again convincingly strengthened on a rat genetic model by Meeren et al.
Its release is synchronized with day-light cycle by a multisynaptic
Anatomical and functional demonstration of a multisynaptic
suprachiasmatic nucleus adrenal (cortex) pathway.
R1 is an ipsilateral monosynaptic response to the stimulation side; R2 is a bilateral oligosynaptic response and R3, also bilateral, follows multisynaptic
The production of the pineal hormone melatonin is synchronized with day-night cycle via multisynaptic
pathway including suprachiasmatic nucleus linking several physiological functions to diurnal cycle.