muscular dystrophy


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Related to muscular dystrophy: multiple sclerosis, Duchenne muscular dystrophy

muscular dystrophy

n. Abbr. MD
Any of a group of progressive muscle disorders caused by a defect in one or more genes that control muscle function and characterized by gradual irreversible wasting of skeletal muscle.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

muscular dystrophy

n
(Pathology) a genetic disease characterized by progressive deterioration and wasting of muscle fibres, causing difficulty in walking
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

mus′cular dys′trophy


n.
a hereditary disease characterized by gradual wasting of the muscles.
[1865–70]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.

mus·cu·lar dys·tro·phy

(mŭs′kyə-lər dĭs′trə-fē)
Any of several hereditary diseases in which a person's muscles gradually deteriorate, causing progressive weakness.
The American Heritage® Student Science Dictionary, Second Edition. Copyright © 2014 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

muscular dystrophy

An inherited disorder in which there is a progressive wasting of muscle.
Dictionary of Unfamiliar Words by Diagram Group Copyright © 2008 by Diagram Visual Information Limited
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.muscular dystrophy - any of several hereditary diseases of the muscular system characterized by weakness and wasting of skeletal muscles
Becker muscular dystrophy - a form of muscular dystrophy that sets in in adolescence or adulthood and progresses slowly but will affect all voluntary muscles; characterized by generalized weakness and muscle wasting that affects limb and trunk muscles first; similar to Duchenne's muscular dystrophy but less severe; inheritance is X-linked recessive (carried by females but affecting only males)
distal muscular dystrophy - a form of muscular dystrophy that sets in between 40 and 60 years of age and is characterized by weakness and wasting of the muscles of the hands and forearms and lower legs; inheritance is autosomal dominant
Duchenne's muscular dystrophy, pseudohypertrophic dystrophy - the most common form of muscular dystrophy; inheritance is X-linked recessive (carried by females but affecting only males)
limb-girdle muscular dystrophy - an autosomal recessive form of muscular dystrophy that appears anywhere from late childhood to middle age; characterized by progressive muscular weakness beginning either in the shoulder or pelvic girdle; usually progresses slowly with cardiopulmonary complications in the later stages
myotonia atrophica, myotonic dystrophy, myotonic muscular dystrophy, Steinert's disease - a severe form of muscular dystrophy marked by generalized weakness and muscular wasting that affects the face and feet and hands and neck; difficult speech and difficulty with the hands that spreads to the arms and shoulders and legs and hips; the onset can be any time from birth to middle age and the progression is slow; inheritance is autosomal dominant
oculopharyngeal muscular dystrophy - a form of muscular dystrophy that usually begins between early adulthood and middle age and first affects muscles of the eyelid and throat; progresses slowly with swallowing problems common as the disease progresses; inheritance is autosomal dominant
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

muscular dystrophy

Collins German Dictionary – Complete and Unabridged 7th Edition 2005. © William Collins Sons & Co. Ltd. 1980 © HarperCollins Publishers 1991, 1997, 1999, 2004, 2005, 2007

muscular dystrophy

ndistrofia muscolare
Collins Italian Dictionary 1st Edition © HarperCollins Publishers 1995
References in periodicals archive ?
Calls cost pounds 1 from a BT landline while mobile costs vary, with 55p going to to the Muscular Dystrophy Campaign.
Greg Smith is a forty-year-old divorced father of three who lives with muscular dystrophy. "He can move and drive and talk," his young daughter explains in Joanne Caputo's documentary, On a Roll, which airs on the PBS series Independent Lens in conjunction with Black History Month.
They restored muscle stem cell function that is impaired in Duchenne muscular dystrophy, resulting in efficient regeneration of the muscle and preventing the progressive loss of muscle strength characteristic of the disease.
Muscular Dystrophy UK's chief executive Catherine Woodhead, said: "Mia has shown remarkable maturity in giving up her time to take on both exhilarating activities and tireless fundraising and she has shown a selfless 'go and do' attitude to make a difference for her brother and others with a muscle wasting condition."
"The results demonstrate that tamoxifen and raloxifene hold significant potential for treating FKRP-related muscular dystrophy and probably other muscular dystrophies," the authors write.
FDA's Office of Tissues and Advanced Therapies told Capricor Therapeutics (CAPR) that under the Regenerative Medicine Advanced Therapy (RMAT) designation, the agency will "work closely" with the company "to provide guidance on the subsequent development of CAP-1002" for the treatment of Duchenne muscular dystrophy, "including providing advice on generating the evidence needed to support approval of the drug in an efficient manner."
- The American Heart Association Scientific Sessions 2017 has accepted for presentation at a late-breaking session the 12-month results from US-based Capricor Therapeutics, Inc.'s (NASDAQ: CAPR) HOPE-1 clinical trial of its lead investigational product, CAP-1002, in boys and young men in advanced stages of Duchenne muscular dystrophy, the company said.
Duchenne muscular dystrophy (DMD) is the most common X-linked recessive disease.3 It involves most serious myopathies affecting approximately 1: 3500 live born males.4 It usually appears between 2 and 5 years of age along with clinical warning sign of muscle weakness in the limbs and pseudo hypertrophic muscles of calf.5 Patients are wheelchair bound at the age of 10-12 years because of the loss of ambulation.6
The "Move a Mile for Muscles" walk was organised by Kate Cartwright of Aberdare, whose son Sonny, six, has the muscle wasting condition Becker muscular dystrophy.
The report provides comprehensive information on the therapeutics under development for Muscular Dystrophy, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.

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