Also found in: Thesaurus, Medical, Legal, Encyclopedia, Wikipedia.


1. The act or process of being altered or changed.
2. An alteration or change, as in nature, form, or quality.
3. Genetics
a. A change in the nucleotide sequence of the genome of an organism or virus, sometimes resulting in the appearance of a new character or trait not found in the parental type.
b. The process by which such a change occurs, either through an alteration in the nucleotide sequence coding for a gene or through a change in the physical arrangement of the genetic material.
c. The nucleotide sequence, trait, or individual that results from such a change.
4. Linguistics
a. A change affecting a sound or a class of sounds, such as back vowels or plosive consonants, through assimilation to another sound, as in the process of umlaut.
b. A change affecting a sound or a class of sounds that is conditioned by morphological or syntactic factors rather than purely phonological factors, as in Irish, where certain words cause the lenition of the initial consonants of the following word.

[Middle English mutacioun, from Old French mutacion, from Latin mūtātiō, mūtātiōn-, from past participle of mūtāre, to change; see mutate.]

mu·ta′tion·al adj.
mu·ta′tion·al·ly adv.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.mutational - of or relating to or resulting from mutation
References in periodicals archive ?
Professor Stratton says: "As cells go through life, they pick up mistakes in the DNA; a cell develops its own distinct mutational 'fingerprint'.
It is known to be resistant to conventional chemotherapy, and although DM tumors typically have high mutational loads, they generally lack driver mutations that could be treated with targeted agents, the investigators noted.
F1CDx reads the order of nucleotides on DNA isolated from biopsy specimens to detect a range of genetic anomalies, including base substitutions, insertion and deletion alterations, copy number alterations, and select gene rearrangements, as well as genomic signatures including microsatellite instability and tumor mutational burden.
Under the agreement, Foundation Medicine will provide genomic testing services for the SPECTA program through three of its genomic profiling assays: FoundationOne, its flagship assay for solid tumor cancers that includes analysis of genomic biomarkers such as microsatellite instability and tumor mutational burden, FoundationOneHeme, an assay for hematologic malignancies and sarcomas that also includes MSI analysis, and FoundationACT, a liquid biopsy assay for solid tumors.
Following maternal plasma DNA sequencing and relative haplotype dosage (RHDO) analysis was used to infer the mutational status of the fetus for inheritance of Mendelian disorders.
The test also reports genomic biomarkers, such as microsatellite instability and tumor mutational burden, that can help inform the use of immunotherapies, genomic alterations in other genes relevant to patient management, and relevant clinical trial information.
He considers transhumanism as part of a utopian rhetoric he calls evolutionary futurism, which situates technology as having mutational, evolutionary pressures on humans, and how it predates the mid-1970s organization of transhumanism into a coherent movement.
M2 EQUITYBITES-September 8, 2017-New blood test developed by Roche and Foundation Medicine able to determine tumour mutational burden
This study adds to the literature on phenotypic and mutational spectrum of the very rare CPDX2 phenotype.
Our study supports the evidence of mutational hotspots in TYR gene causing OCA in Pakistani patients.
RESULTS BRAF Mutational Analysis (note B) --No mutation detected --Mutation identified --p.
3) However, the significance of mutational combinations on Ph-negative MPNs remains unknown.