mutational


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mu·ta·tion

 (myo͞o-tā′shən)
n.
1. The act or process of being altered or changed.
2. An alteration or change, as in nature, form, or quality.
3. Genetics
a. A change in the nucleotide sequence of the genome of an organism or virus, sometimes resulting in the appearance of a new character or trait not found in the parental type.
b. The process by which such a change occurs, either through an alteration in the nucleotide sequence coding for a gene or through a change in the physical arrangement of the genetic material.
c. The nucleotide sequence, trait, or individual that results from such a change.
4. Linguistics
a. A change affecting a sound or a class of sounds, such as back vowels or plosive consonants, through assimilation to another sound, as in the process of umlaut.
b. A change affecting a sound or a class of sounds that is conditioned by morphological or syntactic factors rather than purely phonological factors, as in Irish, where certain words cause the lenition of the initial consonants of the following word.

[Middle English mutacioun, from Old French mutacion, from Latin mūtātiō, mūtātiōn-, from past participle of mūtāre, to change; see mutate.]

mu·ta′tion·al adj.
mu·ta′tion·al·ly adv.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.mutational - of or relating to or resulting from mutation
References in periodicals archive ?
Thus, it appears that daunomycin can induce a wide array of mutational events which include frameshifts and base-substitution mutations.
The nature of radon/radon daughter-induced mutational lesions in human lymphoblasts is also investigated.
Numerous studies in a wide array of species have revealed that the mutational rate of production of new variation for morphological, behavioral, and life-history traits is sufficient to increase heritabilities by approximately 0.1 to 1.0 percent per generation (see reviews in Lande 1976; Lynch 1988; Houle et al.
A second thrust explores the limitations of natural selection as a mechanism for generating order and fitness, showing how evolving systems can get sidetracked by mutational drift, internal complexity, and myopic adherence to local rather than global optima.
Thus, making us of allthese factors may provide models supportive for clinical decision making.Diverse molecular data includinggene expression, mutational patternsand structural genomic alterationas well asdiverse microbiotas, will be collected across several solid cancers.
Bio-Techne announced the publication of a recent validation study demonstrating that the proprietary exosome-based liquid biopsy tests from Bio-Techne's Exosome Diagnostics brand may be used to assess the mutational status of the Epidermal Growth Factor Receptor - or EGFR - gene in patients with non-small cell lung cancer.
NEC and Transgene have capitalised on the recent progress in AI and advances in genome sequencing to create individualized immunotherapy, which is adapted to the unique characteristics of each patient's mutational landscape as well as their predicted immune responses.
ThyGeNEXT is a next generation mutational panel for indeterminate thyroid nodules.
MONDAY, April 16, 2018 (HealthDay News) -- For metastatic non-small-cell lung cancer (NSCLC), the addition of pembrolizumab to standard chemotherapy is beneficial; and nivolumab plus ipilimumab is associated with better survival than chemotherapy for NSCLC with high tumor mutational burden, according to two studies published online April 16 in the New England Journal of Medicine to coincide with the annual meeting of the American Association for Cancer Research, held from April 14 to 18 in Chicago.
It is known to be resistant to conventional chemotherapy, and although DM tumors typically have high mutational loads, they generally lack driver mutations that could be treated with targeted agents, the investigators noted.
The major implication of this research, they say, is that many of the tumor specific changes in DNA or histone methylation that might have been previously interpreted as epigenetic phenomena, are in fact the direct consequences of mutational changes in genes that encode chromatin regulators.
A: BRAF Mutational Analysis.--BRAF mutations occur in up to 50% of melanomas.