cure or substantial reduction in mycologic
burden is a reasonable goal, even in the absence of improvement in appearance.
samples were taken from the appropriate sites on infected patients, and from matching sites on the controls.
Ideally, treatment should result in both mycologic
and clinical cure--or complete cure.
Epidemiologic investigation and mycologic
culture for Sporothrix schenckii implicated hay initially distributed through a commercial hay supplier as the source of the outbreak.
cure rates are the most useful standard to include on product labeling, argued Dr.
WASHINGTON -- Combination treatment of onychomycosis using two topical treatments--40% urea gel and 8% ciclopirox lacquer--resulted in 100% mycologic
cure in a pilot study with 18 patients.
Complete clinical clearance of the nail plus complete mycologic
clearance demonstrated on potassium hydroxide examination and culture
Results of bacteriologic and mycologic
examination of biopsy samples, impression smears, and swab samples from lesions were negative.
Patients treated with 8% ciclopirox alone had an 83.3% rate of mycologic
cure and a 60% rate of clinical improvement.
For example, the cumulative average mycologic
cure rate for terbinafine in 18 randomized controlled trials totalling 993 patients was 76%, compared with 83% in two open studies totalling 391 patients.
Although all mycologic
features and epidemiologic data indicated possible infection by P.
Initial reports of the mycologic
and clinical response rates in randomized trials of itraconazole pulse therapy and fluconazole were significantly higher than the cumulative metaanalysis average response rates for those drugs.