Brain development is a fragile process of myelinogenesis
that continues until about age 25.
It seems that CSF as used in our protocol can mediate glial differentiation and maturation via activation of a subset of genes involving myelinogenesis
. Transition of BMSC to oligodendrocytes is accompanied with a wide range of gene expression changes.
Furthermore, one of the thyroid hormone receptors was found to be necessary for cochlear myelinogenesis
.  Diminished myelin synthesis is also supported by the studies by Delongs and Adams and Bhat et al.
Likely operating under a variety of neurotrophic, survival, and myelinogenesis
pathways, we have identified a novel population of KLF7responsive spinal cord neurons.
Siegel (2012a) identified four fundamental ways experiences can change the structure and function of the brain: (1) synaptogenesis, (2) myelinogenesis
, (3) neurogenesis, and (4) epigenesis.