Statins can lead to myalgia (muscle pain), myopathy, elevated creatin in ekinase (myonecrosis
) and rhabdomyolysis.4,5 Studies have reported that muscle and tendon related side effects were most commonly noticed in patients treated with rosuvastatin while pravastatin and lovastatin have the lowest rate of side effects.6 Onset of myalgia varies from patient to patient and starts after a few weeks to years of statin therapy.7 Myalgia could be generalised or localised, and persists for more than 3 months after discontinuation of statin therapy with average duration of six-and-a-half months.8
Cytotoxin CctA, a major virulence factor of Clostridium chauvoei conferring protective immunity against myonecrosis
. Vaccine, v.30, n.37, p.5500-5, 2012.
Fasciotomy worsens the amount of myonecrosis
in a porcine model of crotaline envenomation.
or inflammatory cell infiltrate was found (Figure 1).
 It is implicated in a wide variety of SSTIs including impetigo, erysipelas, cellulitis, necrotizing fasciitis, myositis and myonecrosis
.  The past two decades have also witnessed a resurgence of several infective syndromes of S.
These include air or gas embolism, clostridial myositis and myonecrosis
(gas gangrene), carbon monoxide poisoning, compartment syndrome, crush injury, and other acute traumatic ischemias, necrotizing soft tissue infections (NSTIs), decompression sickness, arterial insufficiencies, intracranial abscess, severe anemia, refractory osteomyelitis, compromised grafts and flaps, delayed radiation injury (soft tissue and bony necrosis), acute thermal burn injury, and idiopathic sudden sensorineural hearing loss (1).
Muscular dystrophies are a genetically and phenotypically heterogeneous group of muscle diseases characterized by myonecrosis
, regeneration, and endomysial fibrosis leading to progressive muscle wasting.
 did not find any protective effect for three cycles of 3-min RIPostC on the cardiac enzyme levels of cardiac troponin T or MB isoenzyme of creatine kinase (CK-MB), percutaneous coronary intervention (PCI)-related myonecrosis
rate, or myocardial infarction (MI) occurrence.
Thailand had suspended the issuance of import licences for five categories of shrimp last year to prevent the spread of infectious myonecrosis
, a viral disease of penaeid shrimp, based on the guidelines of the World Organisation for Animal Health.
While the beta toxin is known to play a significant role in the pathogenesis of necrotizing enteritis, the alpha toxin is considered responsible for myonecrosis
of infected tissues and is also capable of causing hemolysis.
However, this intervention did not halt the progression of the ongoing myonecrosis
at the amputation site.
Upon dissection into the deep compartment of posterior leg, myonecrosis
of nearly the entire compartment was discovered, and the tibial nerve was surrounded by the necrotic soft tissue (Figure 2).