He said that myxedema
was the name for severe, untreated hypothyroidism, noting that it can result in a medical crisis known as myxedema
coma, in which the patient may lose consciousness as organ functions slow or shut down.
Kadakia, Carlson, and Sataloff  stated that according to Ritter, the mechanism of action of the thyroid hormone to the voice is unknown in patients with hypothyroidism, but it is believed to be related to the increased levels of polysaccharides and the fluid accumulation in the lamina propria in the vocal folds, paresis of the cords due to the thyroid gland enlargement, myxedema
of the cricothyroid muscle, and neural edema of the vagus nerve .
* Nervous System: carpel tunnel syndrome (Dry scaly skin, brittle nails, ape deformity, etc), cerebellar ataxia(impaired coordination, i.e., trouble performing day to day activities like eating with hands, unsteady gait, uncontrolled eye movements, etc), psychosis(myxedema
madness), depression and delayed relaxation of reflexes.
Note that for migraines, thyroid therapy may help, too, as it eliminates the myxedema
, which compresses brain structures inside the non-extendable skull.
(16) Thyroid storm is another notable condition and is a severe stage of hyperthyroidism that is characterized by exaggerated signs and symptoms of hyperthyroidism, varying degrees of organ decompensation, (17) and myxedema
coma, which is the most severe manifestation of hypothyroidism, characterized by a lack of energy that evolves into stupor and eventually coma with associated respiratory failure and hypothermia.
Most serious complication that is rare nowadays is Myxedema
coma; these patients have significant hypothermia and bradycardia.
The pathology may be the result of a local inflammatory (eczema, psoriasis, folliculitis, impetigo, erysipelas, atopic dermatitis and acne conglobata) 4,6,7 or a neoplastic process or systemic illness (leukemia, neurofibroma, myxedema
* Pretibial myxedema
. Patients with pretibial myxedema
will have thyroid function test abnormalities and exhibit other signs of hyperthyroidism.
Other etiologies of pericardial effusion were explored including pericarditis, autoimmune disease, malignancy, and myxedema
; however, history and diagnostic and laboratory evaluations were not consistent with any of these disease processes.
Exclusion criteria included the presence of ischemia, hypertension, diabetes, current use of diuretic or hormonal medications, systemic LL edema resulting from congestive heart disease, renal or hepatic insufficiency, myxedema
, traumatic or rheumatic articular diseases, lymphedema, daily use of compression stockings, and any type of skin lesion.
Besides thyroid hormones, TPE may help in the clearance of cytokines, deiodinase enzyme, and Graves' antibodies which help not only in the resolution of thyrotoxicosis but also of Graves' ophthalmopathy and pretibial myxedema
Ventilatory control in myxedema