- US-based oncolytic immunotherapy company OncoMyx Therapeutics, which was founded on the myxoma virus
platform from Arizona State University, has closed a USD 25m series A financing led by Boehringer Ingelheim Venture Fund, Delos Capital, and Xeraya Capital with participation from Korea Investment Partners, City Hill Ventures, and Madison Partners, the company said.
Now the researchers have found that the myxoma virus
, found in rabbits, can do double duty, quelling the unwanted side effects of a bone marrow transplant and destroying cancer cells, said the study published in the journal Blood.'Myxoma is one of the best strategies because it is effective but does not affect normal stem cells,' said the study's lead investigator Christopher Cogle, associate professor at University of Florida College of Medicine in the US.
This built on the massive reductions achieved in the 1950s from the release of the myxoma virus
, which killed more than 85% of Australias rabbit population.
McFadden, "Myxoma virus
lacking the pyrin-like protein M013 is sensed in human myeloid cells by both NLRP3 and multiple toll-like receptors, which independently activate the inflammasome and NF-[kappa]Binnate response pathways," Journal of Virology, vol.
Current early stage melanoma treatments require minor surgery to cut out the cancer cells and healthy skin around a mole but the new research has created a peptide, or a chain of amino acids, that mimics how the proteins of the myxoma virus
interact with melanoma cells.
M11L: a novel mitochondria-localized protein of myxoma virus
that blocks apoptosis of infected leukocytes.
The European rabbit, on the other hand, can be devastated by the myxoma virus
(22) An example of this involved the natural selection of rabbits resistant to the virulent myxoma virus
, which was documented during several epidemics deliberately induced to control the Australian rabbit population.
Interfering with ecosystems can have dire consequences for biodiversity, as conservation biologist Diana Bell of the University of East Anglia explained: when the South American myxoma virus
was introduced into Europe in the 1950s to control rabbit populations, it contributed to the collapse of a species-rich ecosystem in which the rabbit was the keystone prey for more than 45 predators.
When the myxoma virus
was deliberately introduced as a control measure in Australia in 1950, rabbit populations were decimated.
McFadden and his colleagues have instead pursued studies of myxoma virus
, a variola relative that infects rabbits.
Since the 1930s, the myxoma virus
had been proposed as a biological control agent, but it had proven ineffective in trials.