In a pilot study analyzed by the team, 16 severe OCD patients who underwent therapy and received nabilone
-- a synthetic form of THC that acts on the brain's ECS -- had nearly twice the reduction in symptoms after four weeks compared with their counterparts who received nabilone
alone, or those who received cognitive therapy alone.
The draft NICE guidance looks at most of the cannabis-based medicinal products for treating these conditions, including the licensed products Sativex for treating spasticity in people with multiple sclerosis and nabilone
for treating symptoms of nausea and vomiting in people having chemotherapy.
Some cannabinoids, such as oral medications dronabinol and nabilone
, are prescription medications approved for the treatment of cancer-related side effects.
The cannabinoids approved by the Food and Drug Administration include nabilone
(Cesamet) and dronabinol (Marinol), both synthetic cannabinoids indicated for cancer chemotherapy-related nausea and vomiting, along with cannabidiol (Epidiolex), just approved in June 2018 for treatment of some rare pediatric refractory epilepsy syndromes, Dr.
In fact, the Food and Drug Administration has approved just three (synthetic) THC drugs--Marinol and Syndros (dronabinol) and Cesamet (nabilone
)--to treat nausea and vomiting from chemotherapy.
(145.) Rakesh Jetly et al., The Efficacy of Nabilone
, A Synthetic
sativa plant that contains the cannabinoids THC and CBD; Nabilone
(Cesamet or Canemes)--oral capsules containing a synthetic cannabinoid similar to THC; Dronabinol (Marinol or Syndros)--oral capsules or an oral solution containing synthetic delta-9-THC.
The marketing of synthetic cannabinoid products such as dronabinol and nabilone
by pharmaceutical companies has helped to promote the medical benefits of cannabis and gradually establish it as a legitimate approach to providing patient treatment and care.
Drugs containing synthetic THC (dronabinol, nabilone
) have been approved for use in the United States for CINV, and an oil containing CBD (Epidiolex) has shown promise in controlled trials for managing intractable epilepsy in children.
(20) Tetrahydrocannabinol, other than that which occurs in marijuana in its natural and unaltered state, including any compound, except nabilone
or compounds listed under a different schedule, structurally derived from 6,6' dimethyl-benzo[c]chromene by substitution at the 3-position with either alkyl (C3 to C8), methyl cycloalkyl, or adamantyl groups, whether or not the compound is further modified in any of the following ways ....
, dronabinol] are effective against chemotherapy-induced emesis.