nalmefene


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nal·me·fene

 (năl′mə-fēn′)
n.
A drug, C21H25NO3, used as an antagonist to narcotic drugs.

[nal(trexone) + mefene (probably shortening and alteration of methylene).]
References in periodicals archive ?
The National Institute for Health and Care Excellence (Nice) has published formal guidance recommending nalmefene, following on from draft guidance released in October, which means that patients have the right to request the drug if they meet certain requirements.
Nalmefene is the only licensed medicine to help people reduce their drinking rather than helping them stop completely.
And for most of the off-label medications, "evidence was either insufficient to determine whether they are associated with reduced consumption or evidence suggested that they are not." The exceptions were topiramate, which reduced the number of drinking days, the number of heavy drinking days, and the number of drinks per day; nalmefene, which reduced the number of drinking days per month and drinks per day; and valproic acid.
THE committee who approved nalmefene (the pill that stops you drinking so much) must be the same one who thought methadone would control drug abuse.
According to manufacturers, if dependent drinkers take the drug nalmefene and undergo simultaneous counselling, they can cut their consumption levels by 61 percent, the Scotsman reported.
The other product is Biotie's own Phase III project nalmefene targeting alcohol dependence.
Drugs that attach to the opiate mu receptor that produce effects similar to morphine and exert their maximum effect (5) (e.g., heroin, morphine, methadone) are designated "full opiate agonists"; drugs that attach tightly to the mu opiate receptor and produce no opiate-like effects (e.g., naloxone, naltrexone or nalmefene) are designated "opiate antagonists"; and drugs that attach to the mu opiate receptor with less than full effect (e.g., buprenorphine) are designated "partial opiate agonists." Buprenorphine is a partial opiate agonist at the mu receptor and an antagonist at the kappa receptor.
The treatment options include naltrexone, nalmefene (Revex), methadone, levoalpha-acetylmethadol (LAAM), and buprenorphine.
EVIDENCE BASED ANSWER Naltrexone (ReVia) and nalmefene (Revex) are the most effective agents for treating alcoholism.
For instance, as mentioned earlier, endogenous opioids play a role in mediating alcohol's effects, and opiate antagonist medications (e.g., naltrexone and nalmefene) can be effective for the treatment of alcoholism.
Classes of Promising Neuroprotective Drugs Class Example(s) (*) NMDA receptor antagonists aptiganel hydrochloride, ACEA,1021, eliprodil Calcium/sodium channel nimodipine, nicardipine, lifarizine, blockers fospehnytoin Opioid antagonist nalmefene Neuronal membrane citicoline monosodium stabilizer Novel neuroprotectant lubeluzole (*) NMDA = N-methyl-D-aspartate
M2 PHARMA-March 14, 2019-FDA Grants Purdue Pharma's Nalmefene HCl Injection Fast Track Designation for the Emergency Treatment of Known or Suspected Opioid Overdose