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A synthetic opioid antagonist, C20H23NO4, used in its hydrochloride form to treat addiction to alcohol and to opioid drugs such as heroin.

[Blend of naloxone and tre- (probably alteration of tri-, from the three carbon atoms of the propyl group that distinguishes it from naloxone, of which it is a congener).]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pharmacology) a narcotic antagonist, similar to morphine, used chiefly in the treatment of heroin addiction
[C20: from N-al(lylnor)ox(ymorph)one, + the arbitrary insertion of -trex-]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(nælˈtrɛk soʊn)

a nonaddictive substance, C20H23NO4, used in the treatment of heroin addiction and opiate overdose.
[1970–75; by rearrangement of parts of its chemical name]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.naltrexone - an oral antagonist against the action of opiates
narcotic antagonist - an antagonist used to counteract the effects of narcotics (especially to counteract the depression of respiration)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


n naltrexona
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Trials carried out with naltrexone have confirmed its efficacy in reducing alcohol consumption and relapse rate at the end of three months of treatment for alcoholism (Anton et al., 2006; Bouza et al., 2004; Pettinati, O'Brien, Rabinowitz, Wortman, Oslin et al., 2006; Srisurapanont & Jarusuraisin, 2005).
Another study to determine whether quetiapine plus naltrexone is more effective than naltrexone alone for the treatment of alcohol-dependent patients, a double-blind, randomized clinical trial where eligible alcohol-dependent patients were randomized to receive naltrexone (50mg/day) plus quetiapine (25-200mg/day) or naltrexone (50mg/day) plus placebo for 12 weeks, and afterwards patients received naltrexone alone during 4 additional weeks, it was found that there were no statistically significant differences for any primary drinking outcomes between treatment groups.
In this paper we discuss three National Institute For Health And Care Excellence (NICE)--approved medications (acamprosate, naltrexone and disulfiram) for use in alcohol relapse prevention (2).
Naltrexone can help prevent relapse in recently detoxified patients with alcohol use disorder.
and Orexigen Therapeutics received approval from the FDA for Contrave (naltrexone HCI and bupropion HCI) extended-release tablets as an adjunct to diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater, or 27 kg/ m2 or greater in the presence of at least one weight-related comorbid condition.
In Australia and the United States, a new form of treatment involving the use of a naltrexone implant is rapidly growing.
The medication in the study found to be more effective than some past approaches is extended release Naltrexone, which is administered once a month by injection in a medical setting.
The medication in the study that was found to be more effective than some past approaches was extended-release Naltrexone, which is administered once a month by injection in a medical setting.
Naltrexone is a pure antagonist at the [mu]-opioid receptor, with no intrinsic agonist effects (1).
Disulfiram, naltrexone, acamprosate, methadone, buprenorphine--the medications approved to treat addiction literally can be counted on the fingers of one hand.
In addition, beginning with disulfiram in the late 1940s and more recently with naltrexone and acamprosate along with newer medications "in the pipeline," pharmacotherapy has been demonstrated to be a useful adjunct to behavioral therapies for many people with unhealthy alcohol use, particularly those with alcohol dependence.
Low-Dose Naltrexone for Autoimmune Disease and Cancer