naltrexone


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.

nal·trex·one

 (năl-trĕk′sōn)
n.
A synthetic opioid antagonist, C20H23NO4, used in its hydrochloride form to treat addiction to alcohol and to opioid drugs such as heroin.

[Blend of naloxone and tre- (probably alteration of tri-, from the three carbon atoms of the propyl group that distinguishes it from naloxone, of which it is a congener).]

naltrexone

(nælˈtrɛksəʊn)
n
(Pharmacology) a narcotic antagonist, similar to morphine, used chiefly in the treatment of heroin addiction
[C20: from N-al(lylnor)ox(ymorph)one, + the arbitrary insertion of -trex-]

nal•trex•one

(nælˈtrɛk soʊn)

n.
a nonaddictive substance, C20H23NO4, used in the treatment of heroin addiction and opiate overdose.
[1970–75; by rearrangement of parts of its chemical name]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.naltrexone - an oral antagonist against the action of opiates
narcotic antagonist - an antagonist used to counteract the effects of narcotics (especially to counteract the depression of respiration)
Translations

naltrexone

n naltrexona
References in periodicals archive ?
Naltrexone or acamprosate should be offered as first-line pharmacologic therapy to patients with moderate to severe alcohol use disorder who do not respond to nonpharmacologic therapy alone, according to a practice guideline published by the American Psychiatric Association.
Naltrexone is an antagonist at [mu]-opioid receptors.
While there are apparent concerns with daily-use naltrexone for treatment retention and adherence outside of direct-monitoring centers, long-acting injectable doses or implants seem to result in improved abstinence rates.
Science healthcare company Pfizer (NYSE:PFE) revealed on Friday the receipt of US Food and Drug Administration (FDA) approval for TROXYCA ER (oxycodone hydrochloride and naltrexone hydrochloride) extended-release capsules, for oral use, CII for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
Food and Drug Administration (FDA) has approved TROXYCA ER (oxycodone hydrochloride and naltrexone hydrochloride) extended-release capsules, for oral use, CII for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
The clinic, however, is prescribing smaller doses of Naltrexone daily in tablet form; this costs PS68 for a three-month course.
Another study to determine whether quetiapine plus naltrexone is more effective than naltrexone alone for the treatment of alcohol-dependent patients, a double-blind, randomized clinical trial where eligible alcohol-dependent patients were randomized to receive naltrexone (50mg/day) plus quetiapine (25-200mg/day) or naltrexone (50mg/day) plus placebo for 12 weeks, and afterwards patients received naltrexone alone during 4 additional weeks, it was found that there were no statistically significant differences for any primary drinking outcomes between treatment groups.
In this paper we discuss three National Institute For Health And Care Excellence (NICE)--approved medications (acamprosate, naltrexone and disulfiram) for use in alcohol relapse prevention (2).
Naltrexone can help prevent relapse in recently detoxified patients with alcohol use disorder.
Treatment with naltrexone was associated with reductions in drinking over 3 months in a study of alcohol-dependent adults, but whether these individuals had a polymorphism that has been associated with better responses to the drug in previous studies did not affect outcomes, Dr.
Nonclinical studies suggest that naltrexone and bupropion have effects on two separate areas of the brain involved in the regulation of food intake: the hypothalamus (appetite regulatory center) and the mesolimbic dopamine circuit (reward system).
In Australia and the United States, a new form of treatment involving the use of a naltrexone implant is rapidly growing.