Shikonin is an important naphthoquinone
natural product derived from the roots of L.
2000), has been reported to bioactivate NA to toxic naphthoquinone
metabolites in vitro (Fukami et al.
A methanolic extract and naphthoquinone
fraction of L.
In particular, sea urchin shells have been reported to contain certain compounds with antioxidant and anti-bactericidal effects including echinochrome A and polyhydroxylated naphthoquinone
pigments (Anderson et al.
A new chlorinated red naphthoquinone
from roots of Sesamum indicum.
derivative from Tectona grandis (Linn.
14) Vitamin K compounds share the same 2-methyl-1, 4-naphthoquinone
backbone, yet differ by the substituent on the third carbon of the naphthoquinone
Species are rich in flavonoids [1-4], carbonyl compounds, hydrocarbons , fatty acids , naphthoquinone
, tannins, alkaloids and amino acids [7,8].
derivatives obtained from the Tabebuia avellanedae-isolated lapachol (5), such as [beta]-lapachone (6) and ([+ or -]) 3-hydroxy-[beta]-Nlapachone (7), displayed a considerable inhibitory activity against Staphylococcus aureus growth, with MICs of 8 [micro]g/mL (8 mg/L) for both compounds; however, no bactericidal activity was observed (Minimum Bactericidal Concentration, MBC [greater than or equal to] 512 [micro]g/mL (512 mg/L) (Pereira et al.
84) The active constituents in Pau d'arco are believed to be the naphthoquinone
derivative, lapachol, and its derivatives (ie.
) is a natural naphthoquinone
possessing various pharmacological activities such as antimalarial (16), antimicrobial (17), anticancer (18), cardiotonic (19) and antifertility action (20).
SYNTHESIS OF A SERIES OF NAPHTHOQUINONE
SULFONIC ACID THIOSEMICARBAZONE LIGANDS AND REACTIONS WITH PALLADIUM (II).