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An oral hypoglycemic drug, C19H27NO3, that stimulates the release of insulin from the pancreas and is used to treat type 2 diabetes.

[nate-, origin unknown + -glinide, antidiabetic drug suff.; see repaglinide.]
References in periodicals archive ?
These include sulfonylureas, such as glipizide and glimepiride, and glinides, such as repaglinide (Prandin) and nateglinide (Starlix).
Nateglinide (Starlix) and repaglinide (Prandin) are the agents in this subclass.
Nateglinide (Starlix[R]) Thiazolidinediones Rosiglitazone Reduces production of (Avadia[R]) glucose by liver.
nateglinide [Starlix[R]], repaglinide [Prandin[R]]) increase insulin secretion by a similar mechanism as sulfonylureas, with similar efficacy in reducing HbA1c (Bennett et al.
The pharmacodynamic study was performed in GK rats, a spontaneous type 2 diabetic animal model, and insulinotropic drug nateglinide was chosen as positive control drug.
Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide.
A 59-year-old obese female patient had been diagnosed with type II DM 15 years previously, and she was taking metformin 11 g 2x1/day), sitagliptin (100 mg/day), and nateglinide (120 mg 3x1/day).
The drugs in this class are repaglinide (Prandin) and nateglinide (Starlix).
Repaglinide and nateglinide are non-sulfonylurea secretagogues which act on the ATP-dependent K-channel in the pancreatic beta cells thereby stimulating the release of insulin from the beta cells, similar to sulfonylurea, though the binding site is different.
5% dosing as can hypoglycemia if (Gluconorm[R]) skip dose if a dose is taken nateglinide meal is missed but meal is (Starlix[R]) or add extra missed.
Nateglinide, an insulin secretagogue was found to reverse the impairment of early insulin response after a glucose load which resulted in postprandial hyperglycaemia.
PRESERVE-B: two year efficacy and safety of initial combination therapy with nateglinide or glyburide plus Met formin.