Also found in: Thesaurus, Medical, Encyclopedia.


The natural death of cells or tissues through aging, as distinguished from necrosis or pathological death.

nec′ro·bi·ot′ic (-ŏt′ĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Mentioned in ?
References in periodicals archive ?
In this category of dacryoadenitis, three patients presented with necrobiotic granulomatous inflammation for which they underwent excision biopsy and one was diagnosed as sarcoid and the other two were diagnosed with non-specific adenitis.
Pulmonary necrobiotic nodules have also been seen in patients with IBD and should be differentiated from malignancies and an infection.
Degenerative changes include cytoplasmic rupture, loss of nuclear shape, elongation or indistinct segmentation of granulocyte nuclei, loss of chromatin definition (appear to have liquefied), pyknotic nuclei (necrobiotic forms), degranulation and cytoplasmic vacuolation.
Research variables were; types of cutaneous granuloma with attributes of tuberculous granuloma, cutaneous leishmaniasis, fungal granuloma, foreign body granuloma, leprosy, sarcoid granuloma, malakoplakia and necrobiotic granuloma.
Pronounced hemorrhage and irregular, occasionally necrotic and necrobiotic germ cells were observed in group II testis tissue (grades 2 and 3) (Figure 4).
Kefir has a histopathological preventive attribute in animal model as it lower the necrobiotic changes in acute renal injury.
Lung involvement in rheumatoid arthritis is not uncommon and may present as necrobiotic nodules which are characteristically multiple, peripheral, and thick-walled, resolving with treatment [53] (Figure 13).
The overall features indicated a moderate degree of pathological changes leading to condition of fatty liver with degenerative and ensuing necrobiotic changes (Figures 1(a) and 1(b)).
Granuloma annulare is a necrobiotic disorder and its association diabetes and is not clear.12 In the present study, granuloma annulare was observed in 3 (0.8%) cases.
[10], cyst formation was thought to have resulted from necrobiotic changes in centrally disposed tumor cells.
(5) Lesions such as orbital necrobiotic xanthogranuloma are associated with systemic IgG4-related disease, (6) and all of our 13 cases had dense lymphoplasmacytic infiltrate and increased numbers of eosinophils.