Key Words: Steven Johnson syndrome, Toxic epidermal necrolysis
, Anticonvulsants, Antibiotics, Clinical outcome
 Two cases of toxic epidermal necrolysis
also had associated fever.
CM is a widely prescribed muscle relaxant which has been reported to cause Stevens–Johnson syndrome, toxic epidermal necrolysis
, and fulminant hepatitis.[sup] Etolodac is a NSAID, the culprit drug in DRESS syndrome.
[5,6] There is a wide spectrum of CADR ranging from a transient maculopapular rash to fatal toxic epidermal necrolysis
quetiapine, aripiprazole Hyperpigmentation Phenothiazines Steven-Johnson's syndrome Exanthematous reactions, Hyperpigmentation Antidepressants SSRIs: fluoxetine, Steven-Johnson's escitalopram, syndrome, toxic sertraline, paroxetine; epidermal necrolysis
, SNRIs: venlafaxine, Leukocytoclastic duloxetine; ADT vasculitis, and imipramine, erythematous purpura on amitriptyline, sun-exposed areas were clomipramine, doxepin particularly reported on paroxetine, fluvoxamine Anxiolytics Lorazepam, clonazepam, and fluoxetine buspirone Mood stabilizers Lithium Acne, alopecia, psoriasis onset and exacerbation Valproic acid SJS, alopecia Carbamazepine Exanthematous reactions, SJS Lamotrigine Hypersensitive rash, acne, alopecia, SJS ANGIOEDEMA AND URTICARIA
In 2007, the US Food and Drug Administration (FDA) postmarketing adverse events reported that Asian people are highly susceptible to SJS/toxic epidermal necrolysis
(TEN) compared to Caucasians and issued the FDA Alert .
Depending on the spread, toxic epidermal necrolysis
(TEN) has by far the highest lethality .
Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis
(TEN), and SJS-TEN overlap are considered a spectrum of severe immunologic dermatobullous conditions involving the skin and mucosal membranes and usually triggered by drugs or infections [1, 2].
By consensus definition in 1993, Stevensp--Johnson syndrome was classified separately from the erythema multiforme spectrum and listed under toxic epidermal necrolysis
Aim: Stevens Johnson syndrome and toxic epidermal necrolysis
are severe acute mucocutaneous diseases.
They cover pathophysiology; evaluation, resuscitation, and treatment; wound care, use of antibiotics, and control of burn wound sepsis; nutrition; inhalation injury; general (nonburn) inpatient wound care; toxic epidermal necrolysis
syndrome and Stevens-Johnson syndrome; chemical burns; and pediatric burn management.