Key Words: Steven Johnson syndrome, Toxic epidermal
necrolysis, Anticonvulsants, Antibiotics, Clinical outcome
[11] Two cases of toxic epidermal
necrolysis also had associated fever.
CM is a widely prescribed muscle relaxant which has been reported to cause Stevens–Johnson syndrome, toxic epidermal
necrolysis, and fulminant hepatitis.[sup][5] Etolodac is a NSAID, the culprit drug in DRESS syndrome.
[5,6] There is a wide spectrum of CADR ranging from a transient maculopapular rash to fatal toxic epidermal
necrolysis (TEN).
quetiapine, aripiprazole Hyperpigmentation Phenothiazines Steven-Johnson's syndrome Exanthematous reactions, Hyperpigmentation Antidepressants SSRIs: fluoxetine, Steven-Johnson's escitalopram, syndrome, toxic sertraline, paroxetine; epidermal
necrolysis, SNRIs: venlafaxine, Leukocytoclastic duloxetine; ADT vasculitis, and imipramine, erythematous purpura on amitriptyline, sun-exposed areas were clomipramine, doxepin particularly reported on paroxetine, fluvoxamine Anxiolytics Lorazepam, clonazepam, and fluoxetine buspirone Mood stabilizers Lithium Acne, alopecia, psoriasis onset and exacerbation Valproic acid SJS, alopecia Carbamazepine Exanthematous reactions, SJS Lamotrigine Hypersensitive rash, acne, alopecia, SJS ANGIOEDEMA AND URTICARIA
In 2007, the US Food and Drug Administration (FDA) postmarketing adverse events reported that Asian people are highly susceptible to SJS/toxic epidermal
necrolysis (TEN) compared to Caucasians and issued the FDA Alert [4].
Depending on the spread, toxic epidermal
necrolysis (TEN) has by far the highest lethality [4].
Stevens-Johnson syndrome (SJS), toxic epidermal
necrolysis (TEN), and SJS-TEN overlap are considered a spectrum of severe immunologic dermatobullous conditions involving the skin and mucosal membranes and usually triggered by drugs or infections [1, 2].
By consensus definition in 1993, Stevensp--Johnson syndrome was classified separately from the erythema multiforme spectrum and listed under toxic epidermal
necrolysis (3).
Aim: Stevens Johnson syndrome and toxic epidermal
necrolysis are severe acute mucocutaneous diseases.
They cover pathophysiology; evaluation, resuscitation, and treatment; wound care, use of antibiotics, and control of burn wound sepsis; nutrition; inhalation injury; general (nonburn) inpatient wound care; toxic epidermal
necrolysis syndrome and Stevens-Johnson syndrome; chemical burns; and pediatric burn management.