The ongoing clinical phase III-study is historical as it is the most comprehensive clinical study to ever be conducted regarding necrotizing enterocolitis
, and to IBT's knowledge the most comprehensive clinical study ever on premature infants.
An exclusively human milk diet reduces necrotizing enterocolitis
. Breastfeed Med 2014; 9(4): 184-90.
The role of second-look laparotomy in necrotizing enterocolitis
. J Pediatr Surg.
For all multiple models, we considered covariates such as bronchopulmonary dysplasia, peri-intraventricular hemorrhage, SNAPPE II (Score for Neonatal Acute Physiology with Perinatal extension-II), weight and gestational age at birth, occurrence of necrotizing enterocolitis
Abbreviations NEC: Necrotizing enterocolitis
SIP: Spontaneous intestinal perforation ELBW: Extremely low birth weight VLBW: Very low birth weight PPD: Primary peritoneal drainage PL: Primary laparotomy TPN: Total parenteral nutrition GBA: Gut-brain axis NDI: Neurodevelopmental impairment CNS: Central nervous system ENS: Enteric nervous system HPA: Hypothalamic-pituitary axis OR: Odds ratio RR: Relative risk CI: Confidence interval MDI: Mental developmental index PDI: Psychomotor developmental index RCT: Randomized clinical trial.
No differences were observed for some of the baseline characteristics, including sex (p = 0.52), APGAR scores (at 5minutes) (p = 036), probiotic usage (p = 029), or other disease severity in perforated necrotizing enterocolitis
. Patients in the longer NPO group were more likely to be younger at birth (p = 0083) and had a lower birth weight (p = 0101) than were those with low NPO days, although no statistical significance was observed.
Taylor, "Cost and Cost-Effectiveness of Donor Human Milk to Prevent Necrotizing Enterocolitis
: Systematic Review," Breastfeeding Medicine, vol.
(NEC) is primarily a disease of premature infants, although up to 10% of cases present in term and near-term babies.
(NEC) is often a devastating condition primarily affecting preterm infants and is the most common surgical emergency in that population.
To the Editor: Metaanalysis of randomized trials that tested different probiotics showed a reduction of [approximately equal to] 50% in necrotizing enterocolitis
and all-cause deaths in preterm infants (1).
"We found increased risks of relatively rare outcomes that other studies could not observe, including maternal acute cardiovascular events and neonatal transient tachypnea, necrotizing enterocolitis
, peri- and intraventricular hemorrhage, and retinopathy of prematurity among deliveries to overweight or obese women," they wrote.