22) A retrospective study of nefazodone
also has suggested that it may be an option for treating CSB.
The researchers looked at amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, fluoxetine, imipramine, mirtazapine, nefazodone
, nortriptyline, paroxetine, sertraline, and venlafaxine (Lancet.
In addition to venlafaxine, the researchers looked at amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, fluoxetine, imipramine, mirtazapine, nefazodone
, nortriptyline, paroxetine, and sertraline (Lancet.
If activation occurs, he advised switching patients to a nonactivating antidepressant, such as duloxetine, nefazodone
, or a tricyclic agent, rather than rechallenging them with another SSRI.
The second-generation antidepressants that were assessed included selective serotonin reuptake inhibitors (such as fluoxetine, sertraline, and paroxetine), serotonin norepinephrine reuptake inhibitors (such as venlafaxine and duloxetine), selective serotonin norepinephrine reuptake inhibitors, and bupropion, mirtazapine, nefazodone
, and trazodone.
An Agency for Healthcare Research and Quality (AHRQ) review of antidepressants found that paroxetine, citalopram, and venlafaxine, when compared with other antidepressants (fluoxetine, fluvoxamine, nefazodone
, sertraline), generally were associated with more reports of SD, specifically complaints of erectile dysfunction in men and decreased vaginal lubrication in women.
The second-line agents also include antidepressants with weaker evidence of effectiveness, such as mirtazapine, or medications effective for PTSD but associated with rare but potentially dangerous side effects, such as nefazodone
because of its hepatotoxicity.
The agency also noted that simvastatin should not be used along with the following drugs, which can increase the risk of myopathy: itraconazole, ketoconazole, posaconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone
, gemfibrozil, cyclosporin and danazol.
The anti-depressants taken by women in this analysis included bupropion (113), citalopram (184), escitalopram (21), fluvoxamine (52), nefazodone
(49), paroxetine (148), mirtazepine (68), fluoxetine (61), trazodone (17), venlafaxine (154), and sertraline (61).
The use of eight antidepressants for this type of pain was seen in these publications: four SSRI (citalopram, fluvoxamine, paroxetine, sertraline) and four SNRI (sibutramine, venlafaxine, nefazodone
ha sido estudiado en diferentes estudios abiertos en cuanto a su eficacia en las pesadillas durante el estres postraumatico, y en la mayoria de estos pacientes se ha presentado una reduccion significativa de las pesadillas en seguimientos a 3 y 4 anos (33-38); lo mismo ocurre con la fenelzina, un inhibidor de la monoaminoxidasa, que fue reportada como efectiva en dos diferentes estudios abiertos (39,40).
Reduced drug elimination can result from hepatic and renal insufficiency, decreased hepatic perfusion (7), altered tissue binding properties and drug-drug interactions known to inhibit the CYP3A enzyme, for instance cimetidine, azole antifungals, clarithromycin, diclofenac, doxycycline, erythromycin, imatinib, isoniazid, nefazodone
, nicardipine, propofol, protease inhibitors, quinidine, telithromycin and verapamil.