(48) Other PIs such as nelfinavir
, amprenavir, saquinavir, ritonavir, and darunavir have also been reported to cause urolithiasis.
There is evidence of clinically important drug-drug interactions between cannabis or cannabinoids and the following medications: chlorpromazine, clobazam, clozapine, CNS depressants (e.g., barbiturates, benzodiazepines), disulfiram, hexobarbital, hydrocortisone, ketoconazole, MAO inhibitors, phenytoin, protease inhibitors (indinavir, nelfinavir
), theophylline, tricyclic antidepressants and warfarin.
A study published in the journal BMJ Open Diabetes Research and Care identifies the specific drugs as stavudine or first-generation ARVs including nelfinavir
Ritonavir (2), a peptidomimetic HIV protease inhibitor, was designed to fit the C2-symmetry in the binding site of the protease, while Nelfinavir
(3) was the first protease inhibitor that was not peptidomimetic.
The ART protease inhibitor Nelfinavir
has been shown to have an effect on Her2/neu receptors and therefore may have an anti-tumorigenic effect.
Therapy was initiated after immunologic and viral loads were determined as per WHO criteria.13 A combination of the two nucleoside reverse transcriptase inhibitors (NRTI's), zidovudine (ZDV) and lamivudine (3TC), plus either the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevaripine or the protease inhibitor (PI) nelfinavir
were initiated as per WHO criteria.
Overall, 19 different combinations were prescribed as initial ART, although the combinations zidovudine + lamivudine + efavirenz (ZDV + 3TC + EFV) and zidovudine + lamivudine + nelfinavir
(ZDV + 3TC + NFV) accounted for more than 50.0% of all prescriptions (35.2% and 19.9%, resp.).
Krogstad et al., "Combination nucleoside analog reverse transcriptase inhibitor(s) plus nevirapine, nelfinavir
, or ritonavir in stable antiretroviral therapy-experienced HIV-infected children: week 24 results of a randomized controlled trial--PACTG 377.
Another case of HIV-associated HLH was reported in a 35-year-old male with a CD4 count of 100 cells/mL who was treated with zidovudine, lamivudine, and nelfinavir
with clinical improvement seen within six days .
 The hepatotoxicity of this drug class varies with the specific drug, 30% of patient who are treatment with ritonavir show toxicity, but only 6-7% of those are initiated therapy with saquinavir, nelfinavir
, or indinavir experienced severe hepatotoxicity.
The PIs used were nelfinavir
until 2007, saquinavir, fosamprenavir, lopinavir, atazanavir and, from 2009, darunavir.