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Related to nelfinavir: saquinavir, ritonavir


A protease-inhibiting drug given in the form of its mesylate, often with other drugs, to suppress the replication of HIV.

[nelfi-, of unknown origin + -navir, protease inhibitor suff. (from saquinavir).]
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Noun1.nelfinavir - a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs
protease inhibitor, PI - an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs


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References in periodicals archive ?
Since nelfinavir has already been deemed safe by the FDA and has been used in people for more than a decade, translating it into a breast cancer drug will likely take much less time than creating an entirely new compound.
Major Finding: Of 25 medications tested, 16 were found to inhibit the metabolism of 17R Those with the strongest inhibitory effects were the asthma drug montelukast, and the protease inhibitors nelfinavir and ritonavir, which were associated with 90%-100% inhibition of 17P.
Nelfinavir and nevirapine side effects during pregnancy.
These studies demonstrated that patients who were accidentally exposed to the highest levels of EMS in nelfinavir received doses of the impurity significantly below the threshold at which DNA damage - and therefore cancer or birth defects - can occur.
ACTG 389 compared boosted saquinavir, boosted indinavir, nelfinavir and placebo all dosed twice daily in a large randomised study [10].
PL-100 has potent anti-protease and antiviral activity against wild-type HIV-1 and has a favorable cross-resistance profile as compared to currently- marketed protease inhibitors namely: saquinavir, indinavir, nelfinavir, amprenavir, atazanavir and lopinavir.
On this regimen we can often find a virus that has only learned to resist 3TC, or 3TC and nelfinavir.
Nelfinavir mesylate (NFV) is an HIV protease inhibitor approved for the treatment of HIV infection.
Nelfinavir (Viracept) is also a popular protease inhibitor.
Nelfinavir mesylate (NFV, Viracept), Agouron Pharmaceuticals Approved March 14, 1997 for the treatment of HIV infection when antiretroviral therapy is warranted in adults and pediatrics greater than or equal to 2 years old.
The Food and Drug Administration approved Viracept, known chemically as nelfinavir, for use in children 2 and older, although the company cannot yet say how effective it is for them.
Two more, nelfinavir and VX-748, also show promise.