nephrogenic diabetes insipidus

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Related to nephrogenic diabetes insipidus: dipsogenic diabetes insipidus, Central diabetes insipidus
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Noun1.nephrogenic diabetes insipidus - diabetes insipidus caused by a failure of the kidney to respond to normal levels of vasopressin
diabetes insipidus - a rare form of diabetes resulting from a deficiency of vasopressin (the pituitary hormone that regulates the kidneys); characterized by the chronic excretion of large amounts of pale dilute urine which results in dehydration and extreme thirst
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Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus. Clin Infect Dis 2003 Apr;36(8):1070-1073.
Development of lithium-induced nephrogenic diabetes insipidus is dissociated from adenylcyclase activity.
Identification of mutations in the arginine vasopressin receptor 2 gene causing nephrogenic diabetes insipidus in Chinese patients.
Despite all that, it is considered a safer diuretic than thiazides, being mentioned as a therapeutic option for nephrogenic diabetes insipidus secondary to chronic treatment with lithium (1,4-6,11,13,15).
Abbreviations AVP: Arginine vasopressin DDAVP: Desmopressin CDI: Central diabetes insipidus NDI: Nephrogenic diabetes insipidus PP: Primary polydipsia.
A likely pathophysiologic scenario in our case may have been that tacrolimus induced distal RTA led to nephrocalcinosis and therefore to secondary nephrogenic diabetes insipidus. Insufficient water intake in a diet with high renal solute load and further renal impairment due to enalapril treatment consequently resulted in an acute polyuric renal failure with severe hypernatremic dehydration.
Lithium--induced nephrogenic diabetes insipidus: renal effects of amiloride.
An inadequate response of the kidney, however, to ADH results in nephrogenic diabetes insipidus and both constitute distinct clinical entities.
For example, nephrogenic diabetes insipidus (NDI), the inability to produce concentrated urine, can result from several different malfunctions in the AQP2 system controlled by anti-diuretic hormone (ADH).
Another study found preliminary evidence that PDE-5 inhibition might relieve a rare kidney condition called nephrogenic diabetes insipidus. In the disease, cells fail to assemble a protein necessary for concentrating waste products, a condition that results in copious production of abnormally dilute urine.
Pathogenesis of nephrogenic diabetes insipidus due to chronic administration of lithium in rats.