In summary, the patients were younger, more likely to present later, abuse methamphetamines and have hypertensive nephrosclerosis
, but less likely to be HIV-positive or diabetic, and fewer had HIVAN, diabetic kidney disease or polycystic kidney disease as the underlying cause of their kidney disease.
is the hardening of the walls of small arteries and arterioles of the kidney.
[UKPRwire, Tue Jul 23 2019] The increasing geriatric population and the rising prevalence of kidney disorders like diabetic neuropathy are the major factors driving the growth of the global nephrosclerosis
One study showed that patients with more severe nephrosclerosis
exhibit lower expression of CD34 in the tubulointerstitium (17).
Rest of the patients had diagnoses in non-specific categories like End Stage Renal Disease (ESRD) in 4 patients, interstitial nephritis with granuloma in 2 patients and 1 had findings of malignant nephrosclerosis
. Oedema was present in majority of cases, 42 of 52.
The kidneys had severe arteriolar nephrosclerosis
. Small bilateral renal cell carcinomas were also present.
Furthermore, microembolization-induced ischemia may be used to generate nephrosclerosis
stated that inhibition of fibrosis pathway via TGF-[beta]1 may increase BMP-7 gene expression in hypertensive nephrosclerosis
, tubulointerstitial fibrosis and diabetic nephropathy .
Fat excess also results in a significant decrease in renal weight that may be related to a progressive loss of nephrons due to benign nephrosclerosis
. According to Kovesdy et al.
was the most common etiology (26.1%) and in 24.2% of patients the cause of CKD was not identified.
The first biopsy (04/2003) showed borderline rejection with interstitial edema and mild vascular rejection, but the following biopsies showed mainly chronic changes with signs of nephrosclerosis
, arteriolar hyalinosis, and increasing interstitial fibrosis and tubular atrophy (07/2003, 11/2005, and 08/2009).
 MN: membranous nephropathy; MCD: minimal change disease; LN: lupus nephritis; FSGS: focal segmental glomerulosclerosis; DN: diabetic nephropathy; N: hypertensive nephrosclerosis
; MGN: membranous glomerular nephropathy; MPGN: non-IgA mesangioproliferative GN; HSP: Henoch-Schonlein purpura.