The following warnings and precautions should be taken when administering Cisplatin Injection: Cisplatin produces cumulative nephrotoxicity
which is potentiated by aminoglycoside antibiotics.
A number of factors have been identified as adding risk to the development of TDF-induced nephrotoxicity
including advanced age, low body mass index (BMI), diabetes mellitus (DM), hypertension (HTN), co-use of other nephrotoxic drugs such as protease inhibitors (PI) and didanosine, treatment experience, and genetic polymorphism in transporters involved in regulating TDF intracellular concentration.
Although histological effects of green tea against BPA nephrotoxicity
have not been studied; Sardana used green tea against gentamycin induced nephrotoxicity
D-Serine has been shown to cause nephrotoxicity
in published preclinical studies.
High doses of cisplatin is linked to nephrotoxicity
, hence practitioners are advised to reduce doses when a patient renal function is reduced.
However, its use is restricted because of the development of ototoxicity and nephrotoxicity
. Many studies were designed to reveal the underlying mechanism of its ototoxic and nephrotoxic effects.
, neurotoxicity, ototoxicity, and cardiotoxicity are the known side effects of the drug (2).
, hypertension, and neurotoxicity might develop in a long-term use.11 In this case, the treatment of cyclosporine was very effective without any adverse effect.
Cisplatin (CDDP) is widely used for treating solid cancers; however, it induces nephrotoxicity
caused by oxidative stress.
The prevalence of nephrotoxicity
due to the use of gentamicin has risen from 3 % in 1969 to 20 % over the past decade.
There were no reports of study-drug related treatment emergent adverse events related to nephrotoxicity
(kidney toxicity) for patients receiving treatment with iclaprim, compared to two (0.7%) for vancomycin.
Consequently, RPTECs experience high intracellular drug concentrations, potentially resulting in nephrotoxicity
. Maintaining functional expression of these transporters in vitro is key for the successful prediction of a drug's nephrotoxic potential.