Nerve growth factor
(NGF) is the founding member of the neurotrophin family, [sup] and is essential for the proper development, patterning, and maintenance of the mammalian nervous system.
Molecular basis of congenital insensitivity to pain with anhidrosis (CIPA): mutations and polymorphisms in TRKA (NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor
Bartus and his associates at Ceregene (where he served as chief scientific officer for more than 10 years) developed a viral gene therapy vector bioengineered to express only the gene for human nerve growth factor
(AAV2-NGF, or CERE-110).
Key words: Brain derived nerve growth factor
, cardiovascular disease, atherosclerosis, dyslipidemia, diabetes mellitus
Over the past year, the Food and Drug Administration has put on clinical hold nearly all programs for nerve growth factor
inhibitor (anti-NGF) development, particularly those related to treating knee pain in osteoarthritis.
Modulation of nerve growth factor
in peripheral organs by estrogen and progesterone.
In 1986 Rita Levi-Montalcini and Stanley Cohen received the Nobel Prize for the discovery and study of the Nerve Growth Factor
The anchor study is Nervous, Immune, Endocrine Regulatory Systems and Diseases Associated with Nerve Growth Factor
Co-Secretion, by Idliko Milnar, who works with an immunology and endocrinology company in Debrecen, Hungary.
In the April 2010 PUFA Newsletter and Fats of Life online publications for health professionals and consumers, one study showed that after corneal surgery (such as LASIK) treating eyes with omega 3 DHA plus a nerve growth factor
helped regenerate corneal nerves, which can be damaged by surgery, reducing tear production and causing dry eye syndrome.
It said the drug blocks a chemical called nerve growth factor
, or NGF, which is released at sites where tissues are damaged or inflamed.
GPC works by increasing the number of receptors on brain cells for nerve growth factor
, a signaling protein that spurs production and survival of nerves.
With the addition of the peptide known as nerve growth factor
, differentiation begins: PC12 cells cease dividing and develop the characteristics of neurons, including axonal projections and specialization into either cholinergic or catecholaminergic transmitter systems.