neuraminidase


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Related to neuraminidase: sialic acid, Neuraminidase inhibitor

neu·ra·min·i·dase

 (no͝or′ə-mĭn′ĭ-dās′, -dāz′, nyo͝or′-)
n.
A hydrolytic enzyme that removes sialic acid from glycoproteins and is found in many cells and viruses. It occurs on the surface of influenza viruses and enables the release of newly replicated viruses from infected cells.
[neuramin(ic acid) (neur(o)- + amin(e)) + -id(e) + -ase.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

neuraminidase

(ˌnjʊərəˈmɪnɪdeɪz)
n
(Biochemistry) any of various enzymes, found esp in viruses, that catalyse the breakdown of glucosides containing neuraminic acid, an amino sugar
[C20: from neuramin(ic acid) (from neuro- + amine + -ic) + -ide + -ase]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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References in periodicals archive ?
The conserved protein, called M2, is dwarfed by its neighbors, hemagglutinin and neuraminidase. These capricious, larger molecules have made the flu virus a moving target.
Flu Vaccine Aims at Constant Target
KF918334-KF918341), whereas the sequence analysis of the other 2 samples was focused on hemagglutinin and neuraminidase genes and a few regions of the other genes (nt 159-525 and nt 994-1107 of polymerase basic protein [PB] 2, nt 115-453 and nt 1726-2259 of PB1, nt 19-297 of nucleocapsid protein, and nt 715-981 of matrix protein) to trace the avian virus responsible for the human infections.
Human infection with highly pathogenic A(H7N7) avian influenza virus, Italy, 2013
neuraminidase inhibitor approved in the US for the treatment of acute uncomplicated influenza in adults.
BioCryst Pharmaceuticals Inc files NDA with FDA for peramivir for the treatment of influenza
They have described how to use their newly discovered compounds to interrupt the enzyme neuraminidase's facilitation of influenza's spread.
Meet flu virus' new enemy
The neuraminidases of HiNi viruses also are similar to a neuraminidase in the current vaccine strain.
FDA panel defers decision on next year's influenza vaccine. (Two of Three Strains Should Remain)
Amantadine and rimantadine are approved for treating influenza A, while the neuraminidase inhibitor drugs zanamivir and oseltamivir are approved to treat both influenza A and B [6-8].
Update: Influenza Activity -- United States, 1999-2000 Season
One viral protein, an enzyme called neuraminidase, is required for the bundle to unglue itself so that individual virus particles can infect other cells.
Drug to treat flu also protects against it
Biota Pharmaceuticals Inc and Daiichi Sankyo had entered into a collaboration, commercialisation and license agreement to develop long-acting neuraminidase inhibitors, including laninamivir octanoate, under which, Daiichi Sankyo has obtained exclusive marketing rights to laninamivir octanoate in Japan.
Biota Pharmaceuticals Inc announces approval of Laninamivir Octanoate in Japan for the prevention of influenza
Oseltamivir, an orally administered neuraminidase (NA) inhibitor, is the most prescribed medication for the treatment of persons with influenza virus infections.
Antiviral susceptibility of highly pathogenic avian influenza A(H5N1) viruses isolated from poultry, Vietnam, 2009-2011
Neuraminidase inhibitors (NAIs) are recommended for the control of severe influenza A and B infections (1).
Reduced Susceptibility to Neuraminidase Inhibitors in Influenza B Isolate, Canada

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