Nevertheless, progress has been made in defining the relationship between neurodevelopmental biology and neuroepithelial
tumors, perhaps most remarkably to date in the context of medulloblastoma, (37-41) as well as the relationship between neuroepithelial
progenitor cells, differentiated cells, and neoplasia in the adult human brain.
Surrounding the immature neuroepithelial
tubules, there were mature tissues, which included cartilage, hepatic tissue, salivary components, and squamous epithelium.
Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial
tumour and dysgenesis of the archicortex in epilepsy.
In the vertebrate brain, postmitotic neurons are generated from neuroepithelial
cells and they start to extend long axonal processes and relatively short, branched dendrites after their migration to appropriate brain regions.
According to the WHO, it is an entity of unknown origin, separate from neuroepithelial
WHO 2007 categorises tumours of Central Nervous System into fifteen types which includes Astrocytic tumours, Oligodendroglial tumours, Ependymal tumours, Choroid plexus tumours, other neuroepithelial
tumours, Neuronal and mixed neuronal glial tumours, tumours of the pineal region, embryonal tumours, tumours of cranial and paraspinal nerves, meningeal tumours, tumours of hematopoietic system, germ cell tumours, familial tumour syndromes, tumours of sellar regions and metastatic tumours.
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial
Stem Cells," Stem Cell Reports, 2017; DOI: 10.
Malignant transformation of neuroepithelial
cells is a multistep process driven by the sequential acquisition of genetic alterations.
One recent report notes that Zika can infiltrate and kill both neuroepithelial
stem cells, which give rise to brain cells, and radial glial cells, which can generate newborn neurons and help guide them to their proper place in the brain.
PNET forms in the cerebrum and is composed of poorly differentiated neuroepithelial
cells (MacDonald 2008).
Few have been reported to harbor malignant histological features especially the immature elements from neuroepithelial
Although other rare types of CNS tumors have been reported in NF1, including ependymomas5, me-dulloblastomas6 and dysplastic neuroepithelial
tumors7, oligodendrogiloma is one of these rare tumors suggesting that the incidence of these tumors in NF1 is very low.