Presentations include complete Phase III results from the SAkuraStar study investigating satralizumab for the treatment of neuromyelitis optica spectrum disorder (NMOSD), and new multiple sclerosis (MS) research, which provides insights into disease progression, including data from OCREVUS[R] (ocrelizumab) trials that advance understanding of
neurofilament light chain (NfL) levels as a potential biomarker for predicting disability outcomes.
Uman is widely recognised to possess the leading antibodies available to measure
neurofilament light and has become the provider of choice for biopharmaceutical and diagnostic applications.
3B), and negative for other markers (NSE,
neurofilament, GFAP).
Jucker and his colleagues monitored the development of
neurofilament concentration in these individuals from year to year.
Additionally, the increase in
neurofilament light chain proteins precisely matched the speed at which the precuneus - which plays a role in memory - thinned and shrank.
Neurofilament accumulation in giant axons was detected by electron microscope [Figure 1]d-1f].{Figure 1}
Chitinase-3-like-1 predicted long-term cognitive impairment 1 the PASAT test, and
neurofilament light-chain (NfL) predicted long-term disability in the MS severity scale and nine-hole-Peg-test (57).
Chordoid glioma with calcification and
neurofilament expression: case report and review of the literature.
Merkel cells are located in the epidermis and contain cytokeratin only, whereas the malignant counterpart MCC contains both cytokeratin and
neurofilament proteins and located in the dermis of skin.
The search continues for a validated blood-based biomarker, including
neurofilament light protein, plasma amyloid beta, and plasma tau.
measured osteopontin (OPN: biomarker for inflammation) and
neurofilament heavy chain (NfH: biomarker for axonal injury) in patients with acute optic neuritis and sex- and age-matched healthy controls.
Immunoreactivity for
neurofilament is also observed (Figure 2(f)).
