MG is an acquired, antibody-mediated autoimmune disease of the neuromuscular junction
causing muscle weakness and increased fatigability.
In vitro studies of the ultrastructural changes induced by guanidine in the nerves, muscle fibers and neuromuscular junction
of the mouse diaphragm.
The technology is described in a recent Biomaterials paper by Hesperos CSO James Hickman from the Hybrid Systems Laboratory at the University of Central Florida, "Stem cell derived phenotypic human neuromuscular junction
model for dose response evaluation of therapeutics."
Assessing according to the investigation method applied, all patients were detected to undergo nerve conduction studies: 3271 patients underwent needle EMG, 170 patients underwent single-fiber EMG, a method specific for investigating neuromuscular junction
Evidence of Neuromuscular Junction
Pathology on Repetitive Nerve Stimulation and Single Fiber Electromyography.
(1) Aging-induced neuromuscular junction
(NMJ) remodeling entails reductions in the number of presynaptic vesicles, nerve terminals, and nicotinic acetylcholine receptors (nAChRs) together with an increase in the space at the motor end plate.
Citation: Wenxuan Liu et al., "Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction
degeneration," eLife, 2017; 6 DOI: 10.7554/eLife.26464
In addition, a higher concentration of 5-HT at the neuromuscular junction
leads to constriction of the external urethral sphincter.
As outlined in this review, stepwise medical treatment for OAB is prudent and aimed at either competitively antagonizing the binding of acetylcholine to the muscarinic receptors (antimuscarinics), agonizing or stimulating the beta-3 adrenergic receptors (mirabegron), or blocking the release of acetylcholine at the bladder neuromuscular junction
botulinum, A, B, [C.sub.1], [C.sub.2], D, E, F, and G, all of which interfere with neural transmission by blocking the release of acetylcholine at the neuromuscular junction
(NMJ) and reduce muscle activity.
It has been demonstrated that APPL regulates synaptic structure and promotes synapse differentiation at the neuromuscular junction
Neostigmine acts as a competitive antagonist at the neuromuscular junction
by increasing the level of acetocholine available for binding to nicotinic receptors.