M2 PHARMA-March 2, 2018-EMA Grants Polaryx Therapeutics Orphan Drug Designation for PLX-200 for Treatment of Neuronal
With funding from the National Institutes of Health's BRAIN Initiative, researchers have discovered a trove of neuronal
subtypes and gene regulators, using a new method they developed.
The current study was aimed to observe the neuroprotective effect of metformin against PTZ-induced apoptotic neurodegeneration in human cortical neuronal
Biopharmaceutical company Catalyst Biosciences (NasdaqCM:CBIO) disclosed on Tuesday the launch of a definitive agreement to sell one of its neuronal
nicotinic receptor (NNR) assets for an upfront payment of USD750,000.
Further experiments in wild-type mice showed that experimental lowering of BRCA1 levels in the dentate gyrus caused neuronal
dysfunction and shrinkage, as well as impairments in synaptic plasticity, excessive neuronal
excitability, spatial learning and memory deficits, and increased DNA damage.
The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal
Oxidative stress has been implicated in neuronal
cell death in a variety of neurologic disorders [1-3].
Serotonin is an important neuromodulator of brain development and the structure and function of neuronal
(nerve cell) circuits.
has signed a license agreement with the Salk Institute for Biological Sciences for the rights to commercialize BrainPhys Neuronal
Background: Abnormal neuronal
differentiation plays an important role in central nervous system (CNS) development abnormalities such as Down syndrome (DS), a disorder that results directly from overexpression of genes in trisomic cells.
We show that wiring a neuronal
circuit is much more complex than previously thought," says Ghosh.
They describe the history of neuroscience; the morphology and interrelationships between glial cells and neurones in different parts of the nervous system; the cellular physiology of the different kinds of glial cells; the mechanisms of intra and inter-cellular signaling in glial networks and glial-neuronal
communications; the role of glial cells in synaptic plasticity, neuronal
survival, and the development of the nervous system; the cellular and molecular mechanisms of metabolic neuronal
-glial interactions; and the role of glia in nervous system pathology, including the pathology of glial cells and associated diseases like multiple sclerosis, Alzheimer's, Alexander disease, and Parkinson's disease.