This project is going to take time because even after promising clinical diagnostic criteria have been identified, the only way to validate them will be to wait for neuropathologic
diagnosis at autopsy.
Comparing the carriers with the noncarriers, the study's "very preliminary" data indicate that cognitive decline begins as early as 10 years before the expected onset of symptoms, while neuropathologic
changes start up to 20 years before.
studies and animal models show that exposure to environmental neurotoxicants can determine progressive damage in the substantia nigra many years before the onset of clinical parkinsonism.
CSF is an obvious source of markers reflecting central neuropathologic
features of the disease [e.g., neuronal degeneration, the disturbance of [beta]-amyloid (A[beta]) metabolism with formation of plaques, and hyperphosphorylation of tau leading to formation of neurofibrillary tangles].
Available clinical and neuropathologic
findings were reviewed for 17 suspected CJD deaths referred to NJDHSS and CDC.
We conducted a study to determine whether vestibular nerves in patients with unilateral Meniere's disease whose symptoms are refractory to medical management exhibit neuropathologic
Table 1 compares Chiari I-IV malformations in terms of neuropathologic
findings, clinical presentations and diagnosis, and treatment and outcomes.
Nearly all persons with Down syndrome over the age of 40 manifest neuropathologic
changes characteristic of Alzheimer's disease, including neurofibrillary tangles, neuritic plaques, and neuron cell loss. This contrasts with the findings of several prospective, longitudinal studies which suggest that the average onset of clinical dementia is in patients in their early 50s.[3-5]
The microscopic neuropathologic
changes among these autopsies consisted of a combination of necrosis that preferentially targeted neurons, degenerative changes of the glial and neuronal cells, white matter loss and axonal rarefaction, microcalcifications, microglial aggregates, gliosis, macrophage and mononuclear inflammatory cell infiltrates, neuronophagy, and perivascular lymphocytic cuffing.
features in this group were also unusual, in particular, the accumulation of microplaques within the cerebellum and thalamus, which stained intensely for PrP.
Of these women, 56 had brains that met the neuropathologic
criteria for Alzheimer's disease.
None of the imaging products are close to being approved, but several companies have requested advice from the agency on designing phase III clinical trials for their products, which are used with PET scans to detect amyloid deposits in the brain, one of the two neuropathologic
findings of Alzheimer's disease (AD).