neurotoxicity


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neu·ro·tox·in

 (no͝or′ō-tŏk′sĭn, nyo͝or′-)
n.
A toxin that damages or destroys nerve tissue.

neu′ro·tox′ic (-tŏk′sĭk) adj.
neu′ro·tox·ic′i·ty (-tŏk-sĭs′ĭ-tē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

neurotoxicity

(ˌnjʊərəʊˌtɒkˈsɪsətɪ)
n
(Medicine) med toxicity, or the level thereof, to the nervous system
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
Translations

neu·ro·tox·i·ci·ty

n. neurotoxicidad.
1. la capacidad de una sustancia o agente de destruir o lesionar el tejido nervioso;
2. acción tóxica destructiva, sistema nervioso.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
Lead program ACTR707 has reported no DLTs or serious adverse events of CRS or neurotoxicity through the first three patient cohorts as of May 7, noted Harrison, who would argue that ACTR707 "clearly has a different safety profile" than ACTR087.
Additionally, three of the 12 patients (25 %) experienced neurotoxicity, including one Grade 1, one Grade 2 and one Grade 4 case.
Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes.
* Studies show that PQQ acts on at least three different dementia-producing processes: neurotoxicity, declining brain blood flow, and glucose-induced vascular damage.
However, its clinical benefits are limited owing to its adverse effects, such as ototoxicity, nephrotoxicity, cardiotoxicity, hepatotoxicity, and central and peripheral neurotoxicity [2].
One hundred sixty-nine patients met the inclusion criteria; 121 childhood cancer survivors underwent neurotoxicity assessments at a median of 8.5 years after completion of treatment and were included in the analyses.
In addition to age and performance status, which are well known prognostic factors, symptoms, tumour volume, presence of meningeal dissemination and serum LDH level also significantly influence survival in these patients.1 Chemo-radiation therapy has remained the mainstay of management in patients with PCNSL and is associated with reasonable efficacy but with high incidence of neurotoxicity.
In two new papers, researchers at Fred Hutchinson provide detailed descriptions of the two most common side effects cytokine release syndrome, or CRS, and neurotoxicity. The work was based on a clinical trial of 133 patients with leukemia or non-Hodgkins lymphoma that didnt respond to standard therapies.
Cytarabine blocks progression from the [G.sub.1] to the S phase, thus act specifically in the S phase of the cell cycle.[2] A well-known complication of high-dose cytarabine is neurotoxicity. The pathophysiology of neurotoxicity is not known; however, it is hypothesized as an immune-mediated mechanism.[3]
Even though valacyclovir is generally well tolerated, prescribers should be aware of its potential neurotoxicity, especially in the setting of acute or chronic impairment in renal function.
Although rare, contrast-induced neurotoxicity has been well documented with intravascular use of nonionic low osmolar contrast material [3-7].