(3) Melanoma is very uncommon in patients younger than 10 years (with the exception of specific rare scenarios, such as lesions arising within large congenital melanocytic nevi
), and mimics of melanoma, such as Spitz nevi
, are much more frequent in this age group.
There are variations of epidermal nevi
(EN) that can be composed of superficial epidermal keratinocytes, sebaceous glands, apocrine or eccrine glands, hair follicles, or smooth muscle.
Routine skin exams are essential for patients with a history of dysplastic nevi
as these patients are at risk for developing melanoma.
[3, 4] Risk factors for malignant melanocytic lesions are both genetic and environmental, specially sunlight exposure in light coloured skin people, family history of melanomas, presence of multiple melanocytic nevi
, xeroderma pigmentosum and dysplastic nevi
Most EAC nevi
are symptomatic, but some are asymptomatic and are found incidentally.
Hypertrichotic Becker's nevi
treated with combination 1,550nm non-ablative fractional photothermolysis and laser hair removal.
The third discordant case (lesion 25) was referred to the male patient, 62 years old, renal transplant, using immunosuppressants, with lumbar lesion for unknown time, whose telediagnostic conclusion was melanoma or recurrent nevi
(multicomponent pattern; presence of irregular mesh, stretch marks, spots, erythema, and blue-gray veil).
Schinella, "Blue Nevi
and Other Melanotic Lesions of the Prostate: Report of 3 Cases and Review of the Literature," The Journal of Urology, vol.
These are all nonspecific stimuli, which generally induce inflammatory reactions, promote the release of common inflammatory factors (e.g., TNF-a, IL-6, and heat shock proteins), and initiate the specific immune attacks targeting melanocytes through multiple integrated mechanisms, based on the proposed two-step hypothesis of the KP in vitiligo. As indicated by our previous research  and Mooney et al .'s  histopathological study, intradermal nevi
, usually elevated from the skin surface, are the predominant histological subtype of central nevi
This is beginning to change as new data emerge about gene mutations that can better stratify nevi
into subsets, and "the hope is we will be better able to predict which subsets are associated with melanoma risk either within the lesion itself or poses an increased risk to the patient," he explained.
The purpose of this report is to illustrate some of the OCT-A characteristics associated with two lesions diagnosed clinically as benign choroidal nevi
. In both cases the commercially available Cirrus 5000 with AngioPlex (Zeiss, Jena, Germany) was used, without any subsequent image modification or processing.
Congenital forms are divided according to their dimensions into: small congenital nevi
< 1.5 cm, large ones 1.5-20 cm, gigantic ones > 20 cm; they are, usually, ma cular at birth, barely visible postpartum, intensely pigmented on certain areas such as the scalp.