nodding syndrome

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nod·ding syndrome

A neurological disorder of unknown cause that chiefly affects children in Africa, characterized by episodes of repetitive head nodding, seizures, and cognitive impairment. Also called nodding disease.
References in periodicals archive ?
Objective: Nodding syndrome (NS) is a neurological, incurable syndrome, currently affecting mainly children between 5 and 15 years of age in South Sudan, Uganda and Tanzania.
Nodding syndrome (NS) is a seizure disorder of unknown etiology, predominately affecting children aged 3-18 years in three sub-Saharan countries (Uganda, South Sudan, and Tanzania), with the primary feature of episodic head nodding.
A standardized questionnaire was used to further classify these cases based on the consensus case definition drafted at the first International Scientific Meeting on Nodding Syndrome in July 2012 (7).
Nodding syndrome (NS) is a seizure disorder of unknown etiology that primarily affects children aged 3-18 years.
Nodding syndrome as a distinctive entity was reported from southern Sudan in the 1990s and investigated by local authorities and the World Health Organization (WHO) during 2001-2002 (1,2).
According to media reports and assessments from local officials, there may be as many as 3,000-8,000 cases of nodding syndrome in the districts of Kitgum, Pader, and Lamwo in northern Uganda, and Western and Central Equatoria States in South Sudan (1,15).
Deaths among nodding syndrome patients also are commonly reported but incompletely ascertained.
An American neurotoxicologist investigating the disease for the WHO thinks Nodding Syndrome could be connected to river blindness, a disease transmitted by the black fly.
Bizarre behavior, whether frantic or somnolent, is caused by a growing procession of ailments, among them rabies, nodding syndrome, unexplained epidemic epilepsy associated with onchocerciasis, diphtheric polyneuropathy, acute flaccid paralysis, brucellosis, encephalitis, or various fevers of unknown origin.
On arrival, a case-control study was conducted that included collecting exposure information and biologic specimens to assess the association of nodding syndrome with suspected risk factors.
As part of the outbreak investigation, a descriptive case series and a case-control study to assess for risk factors were conducted in two locations (Witto village and Maridi town) in the state of Western Equatoria, in South Sudan, where cases of nodding syndrome had been reported.
In-depth analysis of these clinical features and comparison with other nodding syndrome reports is under way.