nonallelic

nonallelic

(ˌnɒnəˈliːlɪk)
adj
(Genetics) genetics (of genes) not functioning as or behaving like alleles
References in periodicals archive ?
The RCCX gene cluster on chromosome 6 has been described as the most complex region within the human genome because many anomalous events occur in this region: unequal crossover, nonallelic homologous recombination (NAHR), duplications of genes, pseudogenes, overlapping gene regions, retroviral and transposon insertions, and intergenic recombination.
Further investigation will be important to determine whether alternative epigenetic or nonallelic VHL loss-of-function mutations account for the remainder of sporadic SNs.
Moreover, retrotransposon sequences may mediate genomic rearrangement through nonallelic homologous recombination.
Orth et al., "Evidence for a nonallelic heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p 24 and 17q25," The Journal of Investigative Dermatology, vol.
Nonallelic comorbidities of atopic eczema: an overview of systematic reviews.
The identification of the breakpoints inside Alu elements allows us to hypothesize that the fusion gene was generated by a nonallelic homologous recombination due to the high sequence homology (Figure 2).
While exchange usually takes place between alleles, homologous recombination between nonallelic sequences with high sequence identity may occur when DSBs form in repetitive DNA sequences such as transposable elements and low-copy repeats/segmental duplications, leading to genomic rearrangements [165].
Chirgwin, "Characterization of the two nonallelic genes encoding mouse preproinsulin," Journal of Molecular Evolution, vol.
Approximately 90% of NF1 microdeletions (Types-1, -2, and -3) are recurrent and arise via nonallelic homologous recombination between low-copyrepeats (REPs), which are paralogous regions flanking the NF1 gene.