The RCCX gene cluster on chromosome 6 has been described as the most complex region within the human genome because many anomalous events occur in this region: unequal crossover, nonallelic
homologous recombination (NAHR), duplications of genes, pseudogenes, overlapping gene regions, retroviral and transposon insertions, and intergenic recombination.
Negative results let us focus on nonallelic
causes for symptoms.
Further investigation will be important to determine whether alternative epigenetic or nonallelic
VHL loss-of-function mutations account for the remainder of sporadic SNs.
Moreover, retrotransposon sequences may mediate genomic rearrangement through nonallelic
Orth et al., "Evidence for a nonallelic
heterogeneity of epidermodysplasia verruciformis with two susceptibility loci mapped to chromosome regions 2p21-p 24 and 17q25," The Journal of Investigative Dermatology, vol.
comorbidities of atopic eczema: an overview of systematic reviews.
The identification of the breakpoints inside Alu elements allows us to hypothesize that the fusion gene was generated by a nonallelic
homologous recombination due to the high sequence homology (Figure 2).
While exchange usually takes place between alleles, homologous recombination between nonallelic
sequences with high sequence identity may occur when DSBs form in repetitive DNA sequences such as transposable elements and low-copy repeats/segmental duplications, leading to genomic rearrangements .
Awareness and knowledge of such nonallelic
profile artifacts is an
Chirgwin, "Characterization of the two nonallelic
genes encoding mouse preproinsulin," Journal of Molecular Evolution, vol.
Differential expression of two nonallelic
MyoD genes in developing and adult myotomal musculature of the trout (Oncorhynchus mykiss).
Approximately 90% of NF1 microdeletions (Types-1, -2, and -3) are recurrent and arise via nonallelic
homologous recombination between low-copyrepeats (REPs), which are paralogous regions flanking the NF1 gene.